2. Academic Validation
  3. Antigenotoxic prenylated flavonoids from stem bark of Erythrina latissima

Antigenotoxic prenylated flavonoids from stem bark of Erythrina latissima

  • Phytochemistry. 2017 Sep:141:140-146. doi: 10.1016/j.phytochem.2017.06.003.
Yancho Zarev 1,  Kenn Foubert 2,  Vera Lucia de Almeida 2,  Roel Anthonissen 3,  Esameldin Elgorashi 4,  Sandra Apers 2,  Iliana Ionkova 5,  Luc Verschaeve 6,  Luc Pieters 7
Affiliations

Affiliations

  • 1 Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium; Department of Pharmacognosy, Faculty of Pharmacy, Medical University - Sofia, Str. Dunav 2, 1000, Sofia, Bulgaria.
  • 2 Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.
  • 3 Toxicology, Scientific Institute of Public Health, Juliette Wytsmanstraat 14, 1050, Brussels, Belgium.
  • 4 Toxicology and Ethnoveterinary Medicine, Food, Feed and Veterinary Public Health, ARC-Onderstepoort Veterinary Institute, Private Bag X05, Onderstepoort, 0110, South Africa.
  • 5 Department of Pharmacognosy, Faculty of Pharmacy, Medical University - Sofia, Str. Dunav 2, 1000, Sofia, Bulgaria.
  • 6 Toxicology, Scientific Institute of Public Health, Juliette Wytsmanstraat 14, 1050, Brussels, Belgium; Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.
  • 7 Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium. Electronic address: luc.pieters@uantwerpen.be.
PMID: 28614730 DOI: 10.1016/j.phytochem.2017.06.003
Abstract

A series of prenylated Flavonoids was obtained from antigenotoxic extracts and fractions of stem bark of Erythrina latissima E. Mey (Leguminosae). In addition to five constituents never reported before, i.e. (2S)-5,7-dihydroxy-2-(4-hydroxy-2-(prop-1-en-2-yl)-2,3-dihydrobenzofuran-6-yl)chroman-4-one (erylatissin D), (2S)-5,7-dihydroxy-2-(4-methoxy-2-(prop-1-en-2-yl)-2,3-dihydrobenzofuran-6-yl)chroman-4-one (erylatissin E), 5,7-dihydroxy-3-(4-methoxy-2-(prop-1-en-2-yl)-2,3-dihydrobenzofuran-6-yl)-4H-chromen-4-one (erylatissin F), (2S)-5,7,8'-trihydroxy-2',2'-dimethyl-[2,6'-bichroman]-4-one (erylatissin G) and (2S)-5,7-dihydroxy-8'-methoxy-2',2'-dimethyl-[2,6'-bichroman]-4-one (dihydroabyssinin I), 18 known Flavonoids were identified. Evaluation of the antigenotoxic properties (against genotoxicity induced by aflatoxin B1, metabolically activated) in the Vitotox assay revealed that most Flavonoids were active. Sigmoidin A and B showed the highest activity, with an IC50 value of 18.7 μg/mL, equivalent to that of curcumin (IC50 18.4 μg/mL), used as a reference antigenotoxic compound.

Keywords

Antigenotoxicity; Antimutagenicity; Erythrina latissima; Leguminosae; Prenylated flavonoids.

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