2. Academic Validation
  3. Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin

Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin

  • Nat Immunol. 2017 Sep;18(9):973-984. doi: 10.1038/ni.3791.
Masashi Kanayama 1,  Shengjie Xu 1,  Keiko Danzaki 1,  Jason R Gibson 2,  Makoto Inoue 1,  Simon G Gregory 2 3,  Mari L Shinohara 1 4
Affiliations

Affiliations

  • 1 Department of Immunology, Duke University School of Medicine, Durham, North Carolina, USA.
  • 2 Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA.
  • 3 Department of Neurology, Duke University School of Medicine, Durham, North Carolina, USA.
  • 4 Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
PMID: 28671690 DOI: 10.1038/ni.3791
Abstract

The balance of myeloid populations and lymphoid populations must be well controlled. Here we found that osteopontin (OPN) skewed this balance during pathogenic conditions such as Infection and autoimmunity. Notably, two isoforms of OPN exerted distinct effects in shifting this balance through cell-type-specific regulation of Apoptosis. Intracellular OPN (iOPN) diminished the population size of myeloid progenitor cells and myeloid cells, and secreted OPN (sOPN) increase the population size of lymphoid cells. The total effect of OPN on skewing the leukocyte population balance was observed as host sensitivity to early systemic Infection with Candida albicans and T cell-mediated colitis. Our study suggests previously unknown detrimental roles for two OPN isoforms in causing the imbalance of leukocyte populations.

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