2. Academic Validation
  3. Terpenoids isolated from Chinese liverworts Lepidozia reptans and their anti-inflammatory activity

Terpenoids isolated from Chinese liverworts Lepidozia reptans and their anti-inflammatory activity

  • Bioorg Med Chem. 2018 May 15;26(9):2392-2400. doi: 10.1016/j.bmc.2018.03.040.
Siwen Li 1,  Huanmin Niu 2,  Yanan Qiao 1,  Rongxiu Zhu 3,  Yong Sun 1,  Zhaojie Ren 4,  Huiqing Yuan 2,  Yun Gao 1,  Yi Li 1,  Wang Chen 5,  Jinchuan Zhou 1,  Hongxiang Lou 6
Affiliations

Affiliations

  • 1 Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, Shandong University, No. 44 West Wenhua Road, Jinan 250010, Shandong Province, China.
  • 2 Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan, China.
  • 3 School of Chemistry and Chemical Engineering, Shandong University, Jinan, China.
  • 4 Nature Department, Shandong Museum, No. 11899 Jingshi Road, Jinan City, Shandong Province, China.
  • 5 Vitamin D Research Institute, Shanxi University of Technology, No. 1 Dongyi Road, Hanzhong, Shanxi 723000, China.
  • 6 Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, Shandong University, No. 44 West Wenhua Road, Jinan 250010, Shandong Province, China. Electronic address: louhongxiang@sdu.edu.cn.
PMID: 29655613 DOI: 10.1016/j.bmc.2018.03.040
Abstract

Five new Terpenoids (1-5) including two dollabellane-type, one ent-kaurane-type Diterpenoids and two sesquiterpenoids were isolated from the Chinese liverwort Lepidozia reptans (L.) Dumort., together with nine known Terpenoids (6-14). Their structures were determined on the basis of analysis of MS and NMR spectroscopic data, single-crystal X-ray diffraction and electronic circular dichroism calculations. The selected compounds 1, 2, 6, 7, 9 and 14 were screened for anti-inflammatory activities by the model of LPS-induced nitric oxide (NO) production with macrophage cells, and the mechanism of the active compounds 1 and 2 were further explored.

Keywords

Anti-inflammatory; Liverworts; Terpenoids.

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