2. Academic Validation
  3. Reproductive and developmental toxicity of potassium perfluorohexanesulfonate in CD-1 mice

Reproductive and developmental toxicity of potassium perfluorohexanesulfonate in CD-1 mice

  • Reprod Toxicol. 2018 Jun:78:150-168. doi: 10.1016/j.reprotox.2018.04.007.
Sue Chang 1,  John L Butenhoff 2,  George A Parker 3,  Prägati S Coder 4,  Jeremiah D Zitzow 5,  Ryan M Krisko 5,  James A Bjork 6,  Kendall B Wallace 6,  Jennifer G Seed 7
Affiliations

Affiliations

  • 1 3M Company, Medical Department, St. Paul, MN 55144, United States. Electronic address: s.chang@mmm.com.
  • 2 Salutox, L.L.C., Lake Elmo, MN 55042, United States.
  • 3 Charles River Pathology Associates Inc, Durham NC 27703, United States.
  • 4 Charles River Laboratories, Ashland, OH 44805, United States.
  • 5 3M Company, Medical Department, St. Paul, MN 55144, United States.
  • 6 University of Minnesota Medical School, Duluth, MN 55812, United States.
  • 7 Independent Consultant, Alexandria, VA 22301, United States.
PMID: 29694846 DOI: 10.1016/j.reprotox.2018.04.007
Abstract

Potassium perfluorohexanesulfonate (K+PFHxS) was evaluated for reproductive/developmental toxicity in CD-1 mice. Up to 3 mg/kg-d K+PFHxS was administered (n = 30/sex/group) before mating, for at least 42 days in F0 males, and for F0 females, through gestation and lactation. F1 pups were directly dosed with K+PFHxS for 14 days after weaning. There was an equivocal decrease in live litter size at 1 and 3 mg/kg-d, but the pup-born-to-implant ratio was unaffected. Adaptive hepatocellular hypertrophy was observed, and in 3 mg/kg-d F0 males, it was accompanied by concomitant decreased serum Cholesterol and increased Alkaline Phosphatase. There were no Other toxicologically significant findings on reproductive parameters, hematology/clinical pathology/TSH, neurobehavioral effects, or histopathology. There were no treatment-related effects on postnatal survival, development, or onset of preputial separation or vaginal opening in F1 mice. Consistent with previous studies, our data suggest that the potency of PFHxS is much lower than PFOS in rodents.

Keywords

Cholesterol; Developmental; Liver; Mice; PFHxS; Perfluorohexanesulfonate; Reproductive; Thyroid.

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