2. Academic Validation
  3. Structural Characterization of Terpenoids from Abies holophylla Using Computational and Statistical Methods and Their Biological Activities

Structural Characterization of Terpenoids from Abies holophylla Using Computational and Statistical Methods and Their Biological Activities

  • J Nat Prod. 2018 Aug 24;81(8):1795-1802. doi: 10.1021/acs.jnatprod.8b00245.
Chung Sub Kim 1,  Joonseok Oh 2 3,  Lalita Subedi 4 5,  Sun Yeou Kim 4 5,  Sang Un Choi 6,  Kang Ro Lee 1
Affiliations

Affiliations

  • 1 Natural Products Laboratory, School of Pharmacy , Sungkyunkwan University , Suwon 16419 , Republic of Korea.
  • 2 Department of Chemistry , Yale University , New Haven , Connecticut 06520 , United States.
  • 3 Chemical Biology Institute , Yale University , West Haven , Connecticut 06516 , United States.
  • 4 Gachon Institute of Pharmaceutical Science , Gachon University , Incheon 21936 , Republic of Korea.
  • 5 College of Pharmacy , Gachon University , #191, Hambakmoero , Yeonsu-gu, Incheon 21936 , Republic of Korea.
  • 6 Korea Research Institute of Chemical Technology , Daejeon 34114 , Republic of Korea.
PMID: 30063340 DOI: 10.1021/acs.jnatprod.8b00245
Abstract

Three new Diterpenoids (1-3) and three new triterpenoids (4-6) were isolated from the trunk of Abies holophylla together with 19 known Terpenoids. The chemical structures of 1-6 were determined through NMR and MS data analyses. Also, the structural assignments of some of these compounds were verified and elucidated utilizing computational methods coupled with a statistical procedure (CP3, DP4, and DP4+). All the isolated compounds were evaluated for their cytotoxicity against four human Cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15). In addition, the compounds were tested for their anti-inflammatory effects in lipopolysaccharide-stimulated murine microglia BV2 cells by measuring nitric oxide levels, and for their neuroprotective activity in C6 cells through induction of nerve growth factor.

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