2. Academic Validation
  3. Phloroglucinols from the Roots of Garcinia dauphinensis and Their Antiproliferative and Antiplasmodial Activities

Phloroglucinols from the Roots of Garcinia dauphinensis and Their Antiproliferative and Antiplasmodial Activities

  • J Nat Prod. 2019 Mar 22;82(3):431-439. doi: 10.1021/acs.jnatprod.8b00379.
Rolly G Fuentes 1 2,  Kirk C Pearce 1,  Yongle Du 1,  Andriamalala Rakotondrafara 3,  Ana L Valenciano 4,  Maria B Cassera 4,  Vincent E Rasamison 5,  T Daniel Crawford 1,  David G I Kingston 1
Affiliations

Affiliations

  • 1 Department of Chemistry and the Virginia Tech Center for Drug Discovery , Virginia Tech , Blacksburg , Virginia 24061 , United States.
  • 2 Division of Natural Sciences and Mathematics , University of the Philippines Visayas Tacloban College , 6500 Tacloban City , Philippines.
  • 3 Département d'Ethnobotanique et de Botanique , Centre National d'Application des Recherches Pharmaceutiques , Ambodivoanjo, BP 702, Antananarivo 101 , Madagascar.
  • 4 Department of Biochemistry and Molecular Biology, Center for Tropical and Emerging Global Diseases (CTEGD) , University of Georgia , Athens , Georgia 30602 , United States.
  • 5 Centre National d'Application des Recherches Pharmaceutiques , BP 702, Antananarivo 101 , Madagascar.
PMID: 30354100 DOI: 10.1021/acs.jnatprod.8b00379
Abstract

Garcinia dauphinensis is a previously uninvestigated endemic plant species of Madagascar. The new phloroglucinols dauphinols A-F and 3'-methylhyperjovoinol B (1-7) and six known phloroglucinols (8-13) together with tocotrienol 14 and the three triterpenoids 15-17 were isolated from an ethanolic extract of G. dauphinensis roots using various chromatographic techniques. The structures of the isolated compounds were elucidated by NMR, MS, optical rotation, and ECD data. Theoretical ECD spectra and specific rotations for 2 were calculated and compared to experimental data in order to assign its absolute configuration. Among the compounds tested, 1 showed the most promising growth inhibitory activity against A2870 ovarian Cancer cells, with IC50 = 4.5 ± 0.9 μM, while 2 had good antiplasmodial activity against the Dd2 drug-resistant strain of Plasmodium falciparum, with IC50 = 0.8 ± 0.1 μM.

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