Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria

Affiliations

• 1 Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa.
• 2 Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine , University of Cape Town , Observatory , Cape Town 7925 , South Africa.
• 3 Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina , Universidade de Lisboa , Av. Prof. Egas Moniz , 1649-028 Lisbon , Portugal.
• 4 Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control , University of Pretoria , Private Bag X20 , Hatfield 0028 , South Africa.
• 5 Wits Research Institute for Malaria, Faculty of Health Sciences , University of the Witwatersrand and National Health Laboratory Service , Johannesburg 2193 , South Africa.
• 6 Institute of Infectious Disease and Molecular Medicine , University of Cape Town , Rondebosch 7701 , South Africa.
• 7 Inpharma Consultancy, 6 Dudley Hill Close , Welwyn , Hertfordshire AL60QQ , U.K.
• 8 Department of Medical Parasitology and Infection Biology , Swiss Tropical and Public Health Institute , Basel , Switzerland.
• 9 University of Basel , Basel , Switzerland.
• 10 South African Medical Research Council, Drug Discovery and Development Research Unit , University of Cape Town , Rondebosch 7701 , South Africa.