2. Academic Validation
  3. Itraconazole Induces Regression of Infantile Hemangioma via Downregulation of the Platelet-Derived Growth Factor-D/PI3K/Akt/mTOR Pathway

Itraconazole Induces Regression of Infantile Hemangioma via Downregulation of the Platelet-Derived Growth Factor-D/PI3K/Akt/mTOR Pathway

  • J Invest Dermatol. 2019 Jul;139(7):1574-1582. doi: 10.1016/j.jid.2018.12.028.
Shuang Chen 1,  Kaiwen Zhuang 2,  Kaiyi Sun 2,  Qin Yang 2,  Xin Ran 2,  Xiaoxi Xu 2,  Chan Mu 1,  Bin Zheng 3,  Yanrong Lu 4,  Jun Zeng 5,  Yalin Dai 6,  Sushmita Pradhan 2,  Yuping Ran 7
Affiliations

Affiliations

  • 1 Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; Department of Dermatovenereology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.
  • 2 Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
  • 3 Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.
  • 4 Key Laboratory of Transplant Engineering and Immunology, National Health and Family Planning Commission, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
  • 5 Department of Biochemistry and Molecular Biology, College of Life Sciences, Chongqing Normal University, Chongqing, China.
  • 6 Department of Medical Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
  • 7 Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China. Electronic address: ranyuping@vip.sina.com.
PMID: 30690033 DOI: 10.1016/j.jid.2018.12.028
Abstract

Infantile hemangioma is the most common benign vascular tumor of infancy. We have previously reported that itraconazole, a common Antifungal agent, can clinically improve or cure infantile hemangioma; however, the underlying molecular mechanisms are still unclear. Here, we show that itraconazole treatment significantly inhibits proliferation and promotes Apoptosis of the endothelial cells of mouse hemangioma cell line and infantile primary hemangioma endothelial cell. Itraconazole also remarkably reduced angiogenesis of hemangioma endothelial cell in vitro. We further performed transcriptome profiling via mRNA microarrays in hemangioma endothelial cell upon itraconazole treatment, and identified cytokine-cytokine receptor interaction as the top significantly enriched pathway. Importantly, itraconazole significantly reduced platelet-derived growth factor-D level, resulting in suppression of platelet-derived growth factor-β activation and inhibition of its downstream effectors, such as PI3K, Akt, 4E-BP1, and p70S6K, which are important for cellular growth and survival of infantile hemangioma. In conclusion, our results suggest that platelet-derived growth factor-D is a target of itraconazole in infantile hemangioma.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-12050
    99.69%, PDGFR抑制剂
我们的 Cookie 政策

我们使用 Cookies 和类似技术以提高网站的性能和提升您的浏览体验，部分功能也使用 Cookies 帮助我们更好地理解您的需求，为您提供相关的服务。 如果您有任何关于我们如何处理您个人信息的疑问，请阅读我们的《隐私声明》。

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z