2. Academic Validation
  3. Cannabinoid receptor 2 activation alleviates septic lung injury by promoting autophagy via inhibition of inflammatory mediator release

Cannabinoid receptor 2 activation alleviates septic lung injury by promoting autophagy via inhibition of inflammatory mediator release

  • Cell Signal. 2020 May;69:109556. doi: 10.1016/j.cellsig.2020.109556.
A P Liu 1,  Q H Yuan 2,  B Zhang 3,  L Yang 3,  Q W He 3,  K Chen 3,  Q S Liu 3,  Z Li 4,  J Zhan 5
Affiliations

Affiliations

  • 1 Department of Anesthesiology, Zhongnan Hospital of Wuhan University, 430071 Wuhan, Hubei, People's Republic of China. Electronic address: 1548205583@qq.com.
  • 2 Department of Anesthesiology, Renmin Hospital of Wuhan University, 430060 Wuhan, Hubei, People's Republic of China.
  • 3 Department of Anesthesiology, Zhongnan Hospital of Wuhan University, 430071 Wuhan, Hubei, People's Republic of China.
  • 4 Department of Anesthesiology, Zhongnan Hospital of Wuhan University, 430071 Wuhan, Hubei, People's Republic of China. Electronic address: lz_gdwh@126.com.
  • 5 Department of Anesthesiology, Zhongnan Hospital of Wuhan University, 430071 Wuhan, Hubei, People's Republic of China. Electronic address: anpeng19950808@163.com.
PMID: 32027949 DOI: 10.1016/j.cellsig.2020.109556
Abstract

Septic lung injury is one of main causes of high mortality in severe patients. Inhibition of excessive inflammatory response is considered as an effective strategy for septic lung injury. Previous studies have shown that Cannabinoid Receptor 2 (CB2), a G protein-coupled receptor, play an important role in immunosuppression. Whether CB2 can be used as a therapeutic target for septic lung injury is unclear. The aim of this study is to explore the role of CB2 in sepsis and its potential mechanism. In this study, treatment with HU308, a specific agonist of CB2, could reduce lung pathological injury, decrease the level of inflammatory cytokines and strengthen the expression of autophagy-related gene after cecal ligation puncture (CLP)-induced sepsis in mice. Similar results were obtained in RAW264.7 macrophages after LPS treatment. Furthermore, the effect of HU308 could be blocked by Autophagy blocker 3-MA in vivo and in vitro. These results suggest that CB2 serves as a protective target for septic lung injury by decreasing inflammatory factors, which is associated with the enhancement of Autophagy.

Keywords

Acute lung injury; Autophagy; Cannabinoid receptor 2; Inflammation; Sepsis.

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