2. Academic Validation
  3. Molecular Networking Reveals Serpentinine-Related Bisindole Alkaloids from Picralima nitida, a Previously Well-Investigated Species

Molecular Networking Reveals Serpentinine-Related Bisindole Alkaloids from Picralima nitida, a Previously Well-Investigated Species

  • J Nat Prod. 2020 Apr 24;83(4):1207-1216. doi: 10.1021/acs.jnatprod.9b01247.
Charlotte Fox Alcover 1,  Guillaume Bernadat 1,  Faustin A Kabran 2,  Pierre Le Pogam 1,  Karine Leblanc 1,  Alexander E Fox Ramos 1,  Jean-François Gallard 3,  Elisabeth Mouray 4,  Philippe Grellier 4,  Erwan Poupon 1,  Mehdi A Beniddir 1
Affiliations

Affiliations

  • 1 Équipe "Pharmacognosie - Chimie des Substances Naturelles", Université Paris-Saclay, CNRS, BioCIS, 92290, Châtenay-Malabry, France.
  • 2 Laboratoire de Chimie Organique et Biologique, UFR SSMT, Université Félix Houphouët-Boigny, 22 BP 582 Abidjan 22, Côte d'Ivoire.
  • 3 Institut de Chimie des Substances Naturelles, CNRS, ICSN UPR 2301, Université Paris-Saclay, 21 Avenue de la Terrasse, 91198, Gif-sur-Yvette, France.
  • 4 Unité Molécules de Communication et Adaptation des Microorganismes (MCAM, UMR 7245), Muséum National d'Histoire Naturelle, CNRS, Sorbonne Universités, CP52, 57 Rue Cuvier, 75005, Paris, France.
PMID: 32091210 DOI: 10.1021/acs.jnatprod.9b01247
Abstract

Five new Monoterpene Indole Alkaloids (1-5), including four serpentinine-related bisindoles and one alstonine derivative monomer, have been isolated from the aerial parts of Picralima nitida. Their structures were elucidated by analysis of their HRMS and NMR spectroscopic data, and their absolute configurations were deduced from the comparison of experimental and simulated ECD spectra. In addition, two known compounds (6 and 7), previously undescribed from P. nitida, have also been purified. The compound isolation workflow was guided by a molecular networking-based dereplication strategy. Twenty-three compounds were dereplicated from the EtOH extract of P. nitida and fractions network and were assigned various levels of identification confidence. The antiparasitic activities against Plasmodium falciparum as well as the cytotoxic activity against the MRC-5 cell line were determined for compounds 1-7.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z