2. Academic Validation
  3. Cedrol protects against chronic constriction injury-induced neuropathic pain through inhibiting oxidative stress and inflammation

Cedrol protects against chronic constriction injury-induced neuropathic pain through inhibiting oxidative stress and inflammation

  • Metab Brain Dis. 2020 Oct;35(7):1119-1126. doi: 10.1007/s11011-020-00581-8.
Mohammad Hossein Sakhaee 1,  Seyed Amir Hossein Sayyadi 2,  Nader Sakhaee 3 4,  Hamid R Sadeghnia 5,  Hossein Hosseinzadeh 6 7,  Fahimeh Nourbakhsh 2,  Fatemeh Forouzanfar 8 9
Affiliations

Affiliations

  • 1 Mashhad University of Medical Sciences, Mashhad, Iran.
  • 2 Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 3 Department of mathematics and Natural Sciences, Harris-Stowe State University, St. Louis, MO, 63108, USA.
  • 4 Department of Chemistry, Southern Illinois University Edwardsville, Edwardsville, IL, 62025, USA.
  • 5 Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 6 Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 7 Pharmacodynamics and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 8 Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. forouzanfarf@mums.ac.ir.
  • 9 Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. forouzanfarf@mums.ac.ir.
PMID: 32472224 DOI: 10.1007/s11011-020-00581-8
Abstract

Injured somatosensory nervous system cause neuropathic pain which is quite difficult to treat using current approaches. It is therefore important to find new therapeutic options. We have analyzed cedrol effect on chronic constriction injury (CCI) induced neuropathic pain in rats. The mechanical and thermal hypersensitivity were evaluated using the von Frey filament, radiant heat and acetone drop methods. The changes in the levels of biomarkers of oxidative stress including malondialdehyde (MDA) and total thiol (SH), as well as inflammatory mediators including Tumour Necrosis Factor alpha (TNF-α) and Interleukin 6 (IL-6) were estimated in the lumbar portion (L4-L6) of neuropathic rats. Administration of cedrol attenuated the CCI-induced mechanical and thermal hypersensitivity. CCI produced an increase in MDA along with a reduction in SH levels in the spinal cord of the CCI rats. Reduced levels of SH were restored by cedrol. Also, the levels of MDA were reduced in the cedrol-treated CCI rats compared to the untreated CCI rats. Besides, level of TNF-α and IL-6 increased in the spinal cord of CCI group and cedrol could reverse it. The current study showed that cedrol attenuates neuropathic pain in CCI rats by inhibition of inflammatory response and attenuation of oxidative stress.

Keywords

Cedrol; Inflammation; Medicinal plants; Neuropathic pain; Oxidative stress; Somatosensory neurons.

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