2. Metabolic Enzyme/Protease Anti-infection Apoptosis GPCR/G Protein
  3. Cytochrome P450 Fungal Apoptosis Caspase Platelet-activating Factor Receptor (PAFR)
  4. Cedrol

Cedrol  (Synonyms: (+)-Cedrol; α-Cedrol)

目录号: HY-N2071 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Cedrol 是一种有效的细胞色素 P-450(CYP) 酶竞争性抑制剂。Cedrol 通过诱导细胞周期阻滞和 Caspase 依赖性凋亡 (apoptosis) 发挥抗癌的作用。Cedrol 作为中性粒细胞激动剂，可使细胞对 N-甲酰基肽的后续刺激脱敏。Cedrol 通过抑制氧化应激和炎症来预防慢性收缩性损伤引起的神经性疼痛。此外，Cedrol 还具有抗菌、预防脱发和抗焦虑的作用。

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Cedrol Chemical Structure

Cedrol Chemical Structure

CAS No. : 77-53-2

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥110
In-stock
100 mg ￥100
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Cedrol:

Cedrol 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cedrol is a potent competitive inhibitor of cytochrome P-450(CYP) enzyme. Cedrol plays an anticancer role by inducing cell cycle arrest and Caspase-dependent apoptosis. Cedrol acts as a neutrophil agonist that can desensitize cells to subsequent stimulation of N-formyl peptides. Cedrol prevents neuropathic pain caused by chronic contractile injury by inhibiting oxidative stress and inflammation. In addition, Cedrol has antibacterial, hair loss prevention and anti-anxiety properties[1][2][3][4][5][6][7].

IC50 & Target

CYP2

 

CYP3

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CTX TNA2 IC50
238.3 μM
Compound: Ced
Cytotoxicity against rat CTX TNA2 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against rat CTX TNA2 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 32960603]
CTX TNA2 IC50
254.7 μM
Compound: Ced
Cytotoxicity against rat CTX TNA2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against rat CTX TNA2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32960603]
CTX TNA2 IC50
279.9 μM
Compound: Ced
Cytotoxicity against rat CTX TNA2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against rat CTX TNA2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32960603]
DBTRG-05MG IC50
101.5 μM
Compound: Ced
Cytotoxicity against human DBTRG-05MG cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human DBTRG-05MG cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32960603]
DBTRG-05MG IC50
107.2 μM
Compound: Ced
Cytotoxicity against human DBTRG-05MG cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human DBTRG-05MG cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32960603]
DBTRG-05MG IC50
118.7 μM
Compound: Ced
Cytotoxicity against human DBTRG-05MG cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human DBTRG-05MG cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 32960603]
RG2 IC50
107 μM
Compound: Ced
Cytotoxicity against rat RG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against rat RG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 32960603]
RG2 IC50
89.2 μM
Compound: Ced
Cytotoxicity against rat RG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against rat RG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32960603]
RG2 IC50
93.3 μM
Compound: Ced
Cytotoxicity against rat RG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against rat RG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32960603]
体外研究
(In Vitro)

Cedrol (0-450 μM；24-72 小时) 以剂量和时间依赖的方式抑制 HT-29 和 CT-26 细胞增殖，IC50 值分别为 138.91 和 92.46 µM[4]。
Cedrol (0-225 μM；0-48 小时) 在 HT-29 和 CT-26 细胞中可通过调节细胞周期调节因子 CDK4 和 cyclin D1 的表达，诱导细胞周期阻滞在 G0/G1 期，并通过外源性 (FasL/caspase-8) 和内源性 (Bax/caspase-9) 途径引发细胞凋亡[4]。
Cedrol (0-180 µM；48 小时) 与 5-FU (HY-90006) 联合使用显著降低 HT-29 细胞活率[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cedrol 相关抗体:

Cell Viability Assay[4]

Cell Line: HT-29 and CT-26 cells
Concentration: 0, 14, 28, 56, 112, 225, and 450 μM
Incubation Time: 24, 48, and 72 h
Result: Inhibited the growth of cells in a dose- and time-dependent manner.

Western Blot Analysis[4]

Cell Line: HT-29 and CT-26 cells
Concentration: 180 µM;
0, 135, 180 and 225 µM
Incubation Time: 0, 6, 12, 24 and 48 h;
24 h
Result: Reduced the levels of CDK4 and cyclin D1.
Significantly increased the expression levels of FasL/cleaved-caspase-8, Bax/cleaved-caspase-9 and cleaved-caspase-3 in a time- and dose-dependent manner.
体内研究
(In Vivo)

Cedrol (150 mg/kg；皮下注射；两天一次；20 天) 在结直肠癌小鼠模型中具有抗肿瘤的作用[4]。
Cedrol (200-1600 mg/kg；腹腔注射；单剂量；测试前 30 分钟) 在雌性小鼠中通过 5-羟色胺或多巴胺系统发挥抗焦虑作用[5]。
Cedrol (50-200 mg/kg; 局部涂抹； 27 天) 在 Cyclophosphamide (HY-17420) 诱导的小鼠脱发模型中具有预防脱发的作用[6]。
Cedrol (20-40 mg/kg；腹腔注射；一天一次；14 天) 在大鼠慢性收缩性损伤模型中可通过抑制氧化应激和炎症来缓解神经性疼痛[7]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CT-26 cells treated BALB/c mice aged 10-12 weeks old (20-23 g)[4]
Dosage: 150 mg/kg
Administration: Subcutaneous injection (s.c.); once every 2 days for 10 times
Result: Suppressed the progression of colorectal cancer.
Improved the survival rate of animals.
Animal Model: Female ICR mice aged 5-6 weeks old[5]
Dosage: 200, 400, 800, 1200 and 1600 mg/kg
Administration: Intraperitoneal injection (i.p.); Single dose; 30 min prior to the test
Result: Exhibited anxiolytic activity on the female mice at dose of 1200-1600 mg/kg.
Increased the level of 5-hydroxytryptamine, decreased the level of dopamine.
Reduced the ratio of 5-hydroxyindoleacetic acid/5-hydroxytryptamine, increased the ratio of 3,4-dihydroxyphenyl acetic acid/dopamine.
Animal Model: Cyclophosphamide (HY-17420) treated adult female C57BL/6 mice aged 6 weeks (20 g)[6]
Dosage: 50, 100 and 200 mg/kg
Administration: Topical application; 27 days
Result: Inhibited alopecia in a dose-dependent manner, manifested mild alopecia with 40% suppression at a dose of 200 mg/kg on day 6 of the experiment.
Restored the hair follicles to its nearly normal modality at a dose of 200 mg/kg on day 15 of the experiment.
Promoted hair regrowth on day 11 of the experiment.
Animal Model: Adult male Wistar rats (220-270 g) with chronic constriction injury (CCI)[7]
Dosage: 20 and 40 mg/kg
Administration: Intraperitoneal injection (i.p.); once a day for 14 days
Result: Attenuated the CCI-induced mechanical and thermal hypersensitivity.
Increased the level of total thiol.
Reduced the levels of MDA.
Reduced the levels of TNF-α and IL-6.
分子量

222.37

Formula

C15H26O
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 110 mg/mL (494.67 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.4970 mL 22.4850 mL 44.9701 mL
5 mM 0.8994 mL 4.4970 mL 8.9940 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

请根据您的 实验动物和给药方式 选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 方案 一

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.75 mg/mL (12.37 mM); 悬浊液; 超声助溶

    此方案可获得 2.75 mg/mL的均匀悬浊液，悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例，取 100 μL 27.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水 定容至 1 mL。

    生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
  • 方案 二

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.75 mg/mL (12.37 mM); 澄清溶液

    此方案可获得 ≥ 2.75 mg/mL（饱和度未知）的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 27.5 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液 中，混合均匀。

    2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
请输入您的动物体内配方组成：
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。
方案所需 助溶剂 包括：DMSO， ，均可在 MCE 网站选购。 ，Tween 80，均可在 MCE 网站选购。
计算结果
工作液所需浓度 : mg/mL
储备液配制方法 : mg 药物溶于 μL  DMSO（母液浓度为 mg/mL）。

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。
动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。
连续给药周期超过半月以上，请谨慎选择该方案。
请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热 （超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。
纯度 & 产品资料
参考文献

Cedrol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4970 mL 22.4850 mL 44.9701 mL 112.4252 mL
5 mM 0.8994 mL 4.4970 mL 8.9940 mL 22.4850 mL
10 mM 0.4497 mL 2.2485 mL 4.4970 mL 11.2425 mL
15 mM 0.2998 mL 1.4990 mL 2.9980 mL 7.4950 mL
20 mM 0.2249 mL 1.1243 mL 2.2485 mL 5.6213 mL
25 mM 0.1799 mL 0.8994 mL 1.7988 mL 4.4970 mL
30 mM 0.1499 mL 0.7495 mL 1.4990 mL 3.7475 mL
40 mM 0.1124 mL 0.5621 mL 1.1243 mL 2.8106 mL
50 mM 0.0899 mL 0.4497 mL 0.8994 mL 2.2485 mL
60 mM 0.0750 mL 0.3748 mL 0.7495 mL 1.8738 mL
80 mM 0.0562 mL 0.2811 mL 0.5621 mL 1.4053 mL
100 mM 0.0450 mL 0.2249 mL 0.4497 mL 1.1243 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cedrol77-53-2(+)-Cedrol α-CedrolCytochrome P450FungalApoptosisCaspasePlatelet-activating Factor Receptor (PAFR)CYPsColorectal cancer modelAntianxiety agentAlopeciaChronic constriction injuryHT-29 cellsCT-26 cellsInhibitorinhibitorinhibit

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