2. Academic Validation
  3. The splicing regulatory factor hnRNPU is a novel transcriptional target of c-Myc in hepatocellular carcinoma

The splicing regulatory factor hnRNPU is a novel transcriptional target of c-Myc in hepatocellular carcinoma

  • FEBS Lett. 2021 Jan;595(1):68-84. doi: 10.1002/1873-3468.13943.
Biao Zhang 1 2,  Hai-Yang Wang 1 2,  De-Xi Zhao 3,  Dong-Xing Wang 1 2,  Quan Zeng 1 2,  Jia-Fei Xi 1 2,  Xue Nan 1 2,  Li-Juan He 1 2,  Jun-Nian Zhou 1 2 4,  Xue-Tao Pei 1 2,  Wen Yue 1 2
Affiliations

Affiliations

  • 1 Stem Cell and Regenerative Medicine Lab, Institute of Health Service and Transfusion Medicine, Beijing, China.
  • 2 South China Research Center for Stem Cell & Regenerative Medicine, SCIB, Guangzhou, China.
  • 3 Department of Hepatobiliary Surgery, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
  • 4 Experimental Hematology and Biochemistry Lab, Beijing Institute of Radiation Medicine, China.
PMID: 33040326 DOI: 10.1002/1873-3468.13943
Abstract

Hepatocellular carcinoma (HCC) is the most common liver Cancer with high mortality. Here, we found that hnRNPU is overexpressed in HCC tissues and is correlated with the poor prognosis of HCC patients. Besides, hnRNPU is of high significance in regulating the proliferation, Apoptosis, self-renewal, and tumorigenic potential of HCC cells. Mechanismly, c-Myc regulates hnRNPU expression at the transcriptional level, and meanwhile, hnRNPU stabilizes the mRNA of c-Myc. We found that the hnRNPU and c-Myc regulatory loop exerts a synergistic effect on the proliferation and self-renewal of HCC, and promotes the HCC progression. Taken together, hnRNPU functions as a novel transcriptional target of c-Myc and promotes HCC progression, which may become a promising target for the treatment of c-Myc-driven HCC.

Keywords

c-Myc; hepatocellular carcinoma; hnRNPU; regulatory loop; therapeutic target.

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