2. Academic Validation
  3. Antiplasmodial Oleanane Triterpenoids from Terminalia albida Root Bark

Antiplasmodial Oleanane Triterpenoids from Terminalia albida Root Bark

  • J Nat Prod. 2021 Mar 26;84(3):666-675. doi: 10.1021/acs.jnatprod.0c01119.
Mamadou A Baldé 1,  Emmy Tuenter 1,  Mohamed S Traoré 2 3,  Laura Peeters 1,  An Matheeussen 4,  Paul Cos 4,  Guy Caljon 4,  Tom Vermeyen 5,  Wouter Herrebout 5,  Aliou M Balde 2 3,  Kenn Foubert 1,  Luc Pieters 1
Affiliations

Affiliations

  • 1 Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
  • 2 Department of Pharmacy, University Gamal Abdel Nasser of Conakry, BP 1017, Conakry, Guinea.
  • 3 Research and Valorization Center on Medicinal Plants Dubreka, BP 6411, Conakry, Guinea.
  • 4 Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
  • 5 MolSpec Research Group, Department of Chemistry, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium.
PMID: 33667089 DOI: 10.1021/acs.jnatprod.0c01119
Abstract

Phytochemical investigation of the n-BuOH extract of the roots of Terminalia albida Sc. Elliot (Combretaceae) led to the isolation and identification of 10 oleanane triterpenoids (1-10), among which six new compounds, i.e., albidanoside A (2), albidic acid A (4), albidinolic acid (5), albidienic acid (8), albidolic acid (9), and albidiolic acid (10), and two triterpenoid aglycones, i.e., albidic acid B (6) and albidic acid C (7), were isolated here for the first time from a natural source, along with two known compounds. The structures of these constituents were established by means of 1D and 2D NMR spectroscopy and ESI mass spectrometry. The isolated compounds were evaluated for their antiplasmodial and antimicrobial activity against the chloroquine-resistant strain Plasmodium falciparum K1, Candida albicans, and Staphylococcus aureus. Compounds 1-4, 6, 7, and 8 showed moderate antiplasmodial activity with IC50 values between 5 and 15 μM. None of the tested compounds were active against C. albicans or S. aureus. These findings emphasize the potential of T. albida as a source for discovery of new antiplasmodial compounds.

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