2. Academic Validation
  3. 2,5-dimethyl celecoxib induces apoptosis and autophagy via activation of ROS/JNK axis in nasopharyngeal carcinoma cells

2,5-dimethyl celecoxib induces apoptosis and autophagy via activation of ROS/JNK axis in nasopharyngeal carcinoma cells

  • Aging (Albany NY). 2021 Sep 12;13(17):21483-21496. doi: 10.18632/aging.203488.
Tan Tan 1 2,  Xiangjie Fu 3,  Jiaquan Qu 4,  Miao Zhang 1,  He Chen 1,  Yaochun Wang 1,  Bo Wang 1,  Juan Li 1,  Jie Liu 1,  Peijun Liu 1
Affiliations

Affiliations

  • 1 Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Shanxi 710061, China.
  • 2 Center for Precision Medicine, Affiliated to The First People's Hospital of Chenzhou, University of South China, Chenzhou 423000, China.
  • 3 Department of Blood Transfusion, Clinical Transfusion Research Center, Xiangya Hospital, Central South University, Changsha 410008, China.
  • 4 Cholestatic Liver Diseases Center and Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
PMID: 34511433 DOI: 10.18632/aging.203488
Abstract

2,5-dimethyl celecoxib (DMC), a close derivative of celecoxib, has also been reported to have Anticancer effects. However, the effects and underlying molecular mechanisms of DMC with respect to nasopharyngeal carcinoma are still largely unknown. In this study, we present that DMC has displayed Anticancer potency in nasopharyngeal carcinoma in vitro and in vivo. Mechanistically, we found DMC induced Apoptosis and Autophagy for Anticancer therapy against nasopharyngeal carcinoma. Furthermore, DMC-induced Autophagy could remarkably attenuate after the treatment of Reactive Oxygen Species (ROS) scavenger N-acetyl cysteine (NAC) and c-Jun N-terminal kinase (JNK) inhibitor SP600125 (SP). Taken together, these results suggested DMC induced Apoptosis and autophagic death via activation of ROS/JNK axis in NPC cells, which providing us new insights into developing potential therapeutic agents for nasopharyngeal carcinoma patients.

Keywords

2,5-dimethyl celecoxib; apoptosis; autophagy; nasopharyngeal carcinoma.

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