TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization

Affiliations

• 1 Department of Neurology, Huashan Hospital and Institute of Neurology, State Key Laboratory of Genetic Engineering, School of Life Sciences, MOE Engineering Research Center of Gene Technology, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University, Shanghai, China.
• 2 Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, China.
• 3 Division of Natural Science, Duke Kunshan University, Suzhou, Jiangsu, China.
• 4 Key Laboratory of Marine Ecosystem Dynamics, Ministry of Natural Resources & Second Institute of Oceanography, Ministry of Natural Resources, Hangzhou, China.
• 5 State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
• 6 Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
• 7 Department of Medical Biophysics, University of Toronto, and Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada.
• 8 Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
• 9 Department of Neurology, Huashan Hospital and Institute of Neurology, Fudan University, Shanghai, China. xiangjchen@fudan.edu.cn.
• 10 Department of Neurology, Huashan Hospital and Institute of Neurology, State Key Laboratory of Genetic Engineering, School of Life Sciences, MOE Engineering Research Center of Gene Technology, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University, Shanghai, China. lijixi@fudan.edu.cn.
• # Contributed equally.