2. Academic Validation
  3. Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review

Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review

  • Pharmaceuticals (Basel). 2021 Oct 29;14(11):1104. doi: 10.3390/ph14111104.
Javad Mottaghipisheh 1,  Hadi Taghrir 2,  Anahita Boveiri Dehsheikh 3,  Kamiar Zomorodian 4,  Cambyz Irajie 5,  Mohammad Mahmoodi Sourestani 3,  Aida Iraji 6 7
Affiliations

Affiliations

  • 1 Center for Molecular Biosciences (CMBI), Institute of Pharmacy/Pharmacognosy, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria.
  • 2 Department of Medicinal Chemistry, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz 71468-64685, Iran.
  • 3 Department of Horticultural Science, Faculty of Agriculture, Shahid Chamran University of Ahvaz, Ahvaz 61357-43311, Iran.
  • 4 Department of Medical Mycology and Parasitology, School of Medicine, Shiraz University of Medical Sciences, Shiraz 14336-71348, Iran.
  • 5 Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran.
  • 6 Central Research laboratory, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran.
  • 7 Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran.
PMID: 34832886 DOI: 10.3390/ph14111104
Abstract

Many Flavonoids, as eminent phenolic compounds, have been commercialized and consumed as dietary supplements due to their incredible human health benefits. In the present study, a bioactive flavone glycoside linarin (LN) was designated to comprehensively overview its phytochemical and biological properties. LN has been characterized abundantly in the Cirsium, Micromeria, and Buddleja species belonging to Asteraceae, Lamiaceae, and Scrophulariaceae families, respectively. Biological assessments exhibited promising activities of LN, particularly, the remedial effects on central nervous system (CNS) disorders, whereas the remarkable sleep enhancing and sedative effects as well as AChE (acetylcholinesterase) inhibitory activity were highlighted. Of note, LN has indicated promising anti osteoblast proliferation and differentiation, thus a bone formation effect. Further biological and pharmacological assessments of LN and its optimized semi-synthetic derivatives, specifically its therapeutic characteristics on osteoarthritis and osteoporosis, might lead to uncovering potential drug candidates.

Keywords

bioactivities; chemotaxonomy; flavonoids; linarin; phytochemistry.

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