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  3. Anti-diabetic potential of β-boswellic acid and 11-keto-β-boswellic acid: Mechanistic insights from computational and biochemical approaches

Anti-diabetic potential of β-boswellic acid and 11-keto-β-boswellic acid: Mechanistic insights from computational and biochemical approaches

  • Biomed Pharmacother. 2022 Mar:147:112669. doi: 10.1016/j.biopha.2022.112669.
Ajmal Khan 1,  Imran Khan 2,  Sobia Ahsan Halim 1,  Najeeb Ur Rehman 1,  Nasiara Karim 3,  Waqar Ahmad 3,  Majid Khan 4,  Rene Csuk 5,  Ahmed Al-Harrasi 6
Affiliations

Affiliations

  • 1 Natural and Medical Sciences Research Center, University of Nizwa, P.O Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, Sultanate of Oman.
  • 2 Department of Pharmacy, University of Swabi, KPK, Pakistan.
  • 3 Department of Pharmacy, University of Malakand, Chakdara 18800, KPK, Pakistan.
  • 4 Natural and Medical Sciences Research Center, University of Nizwa, P.O Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, Sultanate of Oman; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
  • 5 Martin-Luther-University Halle-Wittenberg, Organic Chemistry, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany.
  • 6 Natural and Medical Sciences Research Center, University of Nizwa, P.O Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, Sultanate of Oman. Electronic address: aharrasi@unizwa.edu.om.
PMID: 35121344 DOI: 10.1016/j.biopha.2022.112669
Abstract

β-Boswellic acid (β-BA) and 11-keto-β-boswellic acid (β-KBA) are crucial bioactive compounds, mostly isolated from frankincense. These compounds are known for their potent Anticancer and anti-inflammatory activities. Herein, we have explored the complete anti-diabetic potential of β-BA and β-KBA with detailed parameters. This research revealed that treatment with β-BA and β-KBA at a dose of 1, 2, and 10 mg/kg body weight for 21 days significantly improved body weight loss, water consumption, and specifically the concentration of blood glucose level (BGL) in diabetic Animals, which indicated that the β-BA and β-KBA possess strong anti-diabetic activities. Serum total superoxide dismutase (SOD) and malondialdehyde (MDA) assays were also performed to evaluate the antioxidant effects. The biochemical analysis revealed that these compounds improve an abnormal level of several biochemical parameters like serum lipid values including total Cholesterol (TC), triacylglycerol (TG), low-density lipoprotein Cholesterol (LDL-C) to a normal level and the high-density lipoprotein Cholesterol level (HDL-C). To understand the mechanism of action of β-BA and β-KBA, their most probable biological targets were searched through the inverse docking approach. Our computational analysis reflects that among other probable targets, the Dipeptidyl Peptidase 4 (DPP-4) Enzyme could be one of the possible binders of β-BA and β-KBA to produce their anti-diabetic activities. These in-silico results were validated by an in-vitro experiment. It indicates that the anti-diabetic effects of β-BA and β-KBA are produced by the inhibition of DDP-4. Thus, these anti-diabetic, antioxidant, and anti-hyperlipidemic effects of β-BA and β-KBA suggest these compounds as potential therapeutics for diabetic conditions.

Keywords

11-keto-β-boswellic acid; Dipeptidyl peptidase 4; Glibenclamide; Hypoglycemic; Streptozotocin-induced diabetes; β-Boswellic acid.

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