2. Academic Validation
  3. A minimalist and robust chemo-photothermal nanoplatform capable of augmenting autophagy-modulated immune response against breast cancer

A minimalist and robust chemo-photothermal nanoplatform capable of augmenting autophagy-modulated immune response against breast cancer

  • Mater Today Bio. 2022 May 13;15:100289. doi: 10.1016/j.mtbio.2022.100289.
Hui Ming 1,  Bowen Li 1,  Hailong Tian 1,  Li Zhou 1,  Jingwen Jiang 1,  Tingting Zhang 1,  Ling Qiao 2,  Peijie Wu 2,  Edouard C Nice 3,  Wei Zhang 4 5,  Weifeng He 6,  Canhua Huang 1,  Haiyuan Zhang 7
Affiliations

Affiliations

  • 1 State Key Laboratory of Biotherapy and Cancer Center, West China Hospital and West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, PR China.
  • 2 School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • 3 Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, 3800, Australia.
  • 4 West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
  • 5 Mental Health Center and Psychiatric Laboratory, The State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, China.
  • 6 Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burn and Combined Injury, Chongqing Key Laboratory for Disease Proteomics, Army Military Medical University, Chongqing, 400038, China.
  • 7 School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, China.
PMID: 35634171 DOI: 10.1016/j.mtbio.2022.100289
Abstract

Previously used in anti-fungal therapy, itraconazole has now been shown to be successful in treating advanced breast Cancer (NCT00798135). However, its poor solubility still restricts its application in clinical treatment. There is therefore an urgent need for combined methods to enhance the therapeutic effect of itraconazole (IC) in breast Cancer treatment. With this goal, co-assembled IC/IR820 NPs with synergistic photonic hyperthermia and itraconazole payloads have been constructed to overcome these shortcomings. The IC/IR820 NPs show an enhanced therapeutic effect on breast Cancer by inducing Reactive Oxygen Species (ROS)-mediated Apoptosis and autophagic death. Further evaluation in a mouse model has shown impressive effects of the IC/IR820 NPs on both inhibiting tumor metastasis and activating immunity to prevent tumor recurrence. Mechanistically, itraconazole may promote both tumor cell antigen presentation through Autophagy and the activation of dendritic cells to induce an immune response, which displays a synergistic effect with the immune response generated by photothermal therapy to inhibit tumor recurrence. This strategy of combining itraconazole and IR820 into one minimalist and robust nanoplatform through co-assembly results in excellent therapeutic efficacy, suggesting its potential application as an alternative method for the clinical treatment of breast Cancer.

Keywords

Autophagy; Breast cancer; IR820; Immunotherapy; Itraconazole; Photothermal therapy.

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