Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors

Affiliations

• 1 Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK.
• 2 Department of Chemistry, University of Oxford, Oxford, OX1 3QR, UK.
• 3 Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
• 4 Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
• 5 Institute of Pharmaceutical Sciences, University of Freiburg, 79104, Freiburg, Germany.
• 6 GlaxoSmithKline, Gunnels Wood Rd, Stevenage, SG1 2NY, UK.
• 7 Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK. martine.abboud@lau.edu.
• 8 Department of Natural Sciences, Lebanese American University, Byblos/Beirut, Lebanon. martine.abboud@lau.edu.
• 9 Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK. christopher.schofield@chem.ox.ac.uk.
• # Contributed equally.