2. Academic Validation
  3. Utilization of macrocyclic peptides to target protein-protein interactions in cancer

Utilization of macrocyclic peptides to target protein-protein interactions in cancer

  • Front Oncol. 2022 Nov 17:12:992171. doi: 10.3389/fonc.2022.992171.
Jiawen Yang 1 2 3,  Qiaoliang Zhu 1,  Yifan Wu 2 4 5,  Xiaojuan Qu 2 4 5,  Haixia Liu 2 5 6,  Biao Jiang 2 6,  Di Ge 1,  Xiaoling Song 2
Affiliations

Affiliations

  • 1 Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
  • 2 Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.
  • 3 Shanghai Clinical Research and Trial Center, Shanghai, China.
  • 4 School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
  • 5 University of Chinese Academy of Sciences, Beijing, China.
  • 6 School of Physical Science and Technology, ShanghaiTech University, Shanghai, China.
PMID: 36465350 DOI: 10.3389/fonc.2022.992171
Abstract

Protein-protein interactions (PPIs) play vital roles in normal cellular processes. Dysregulated PPIs are involved in the process of various diseases, including Cancer. Thus, these PPIs may serve as potential therapeutic targets in Cancer treatment. However, despite rapid advances in small-molecule drugs and biologics, it is still hard to target PPIs, especially for those intracellular PPIs. Macrocyclic Peptides have gained growing attention for their therapeutic properties in targeting dysregulated PPIs. Macrocyclic Peptides have some unique features, such as moderate sizes, high selectivity, and high binding affinities, which make them good drug candidates. In addition, some oncology macrocyclic peptide drugs have been approved by the US Food and Drug Administration (FDA) for clinical use. Here, we reviewed the recent development of macrocyclic Peptides in Cancer treatment. The opportunities and challenges were also discussed to inspire new perspectives.

Keywords

cancer; drug; macrocyclic peptide; protein-protein interactions; treatment.

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