Age-related matrix stiffening epigenetically regulates α-Klotho expression and compromises chondrocyte integrity

Affiliations

• 1 Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA. iijima@met.nagoya-u.ac.jp.
• 2 Japan Society for the Promotion of Science, Tokyo, Japan. iijima@met.nagoya-u.ac.jp.
• 3 Institute for Advanced Research, Nagoya University, Nagoya, Japan. iijima@met.nagoya-u.ac.jp.
• 4 Medical Scientist Training Program, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
• 5 Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
• 6 Cellular and Molecular Pathology Graduate Program, University of Pittsburgh, Pittsburgh, PA, USA.
• 7 Discovery Center for Musculoskeletal Recovery, Schoen Adams Research Institute at Spaulding, Boston, MA, USA.
• 8 Department of Physical Medicine & Rehabilitation, Harvard Medical School, Boston, MA, USA.
• 9 Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA.
• 10 McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
• 11 Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
• 12 Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA.
• 13 Petersen Institute of Nanoscience and Engineering, University of Pittsburgh, Pittsburgh, PA, USA.
• 14 Department of Motor Function Analysis, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
• 15 Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, USA.
• 16 Department of Physical Medicine & Rehabilitation, Mayo Clinic, Rochester, MN, USA.
• 17 Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA. fambrosio@mgh.harvard.edu.
• 18 Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA. fambrosio@mgh.harvard.edu.
• 19 Discovery Center for Musculoskeletal Recovery, Schoen Adams Research Institute at Spaulding, Boston, MA, USA. fambrosio@mgh.harvard.edu.
• 20 Department of Physical Medicine & Rehabilitation, Harvard Medical School, Boston, MA, USA. fambrosio@mgh.harvard.edu.
• 21 McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA. fambrosio@mgh.harvard.edu.
• 22 Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA. fambrosio@mgh.harvard.edu.
• 23 Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA. fambrosio@mgh.harvard.edu.