2. Academic Validation
  3. An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment

An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment

  • Nat Commun. 2023 May 31;14(1):3159. doi: 10.1038/s41467-023-38597-0.
Guoqing Li # 1 2,  Su Liu # 1 2,  Yixiao Chen # 1 2,  Jin Zhao 1 2,  Huihui Xu 1 2,  Jian Weng 1 2,  Fei Yu 1 2,  Ao Xiong 1 2,  Anjaneyulu Udduttula 3,  Deli Wang 1 2,  Peng Liu 4 5,  Yingqi Chen 6 7,  Hui Zeng 8 9 10
Affiliations

Affiliations

  • 1 Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, 518036, PR China.
  • 2 National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, 518036, PR China.
  • 3 Centre for Biomaterials, Cellular and Molecular Theranostics (CBCMT), Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, 632014, India.
  • 4 Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, 518036, PR China. liupeng_polymer@126.com.
  • 5 National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, 518036, PR China. liupeng_polymer@126.com.
  • 6 Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, 518036, PR China. yqchen0203@foxmail.com.
  • 7 National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, 518036, PR China. yqchen0203@foxmail.com.
  • 8 Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, 518036, PR China. zenghui_36@163.com.
  • 9 National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, 518036, PR China. zenghui_36@163.com.
  • 10 Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, 1120 Lianhua Road, Futian District, Shenzhen, Guangdong Province, PR China. zenghui_36@163.com.
  • # Contributed equally.
PMID: 37258510 DOI: 10.1038/s41467-023-38597-0
Abstract

Intra-articular injection of therapeutics is an effective strategy for treating osteoarthritis (OA), but it is hindered by rapid drug diffusion, thereby necessitating high-frequency injections. Hence, the development of a biofunctional hydrogel for improved delivery is required. In this study, we introduce a liposome-anchored teriparatide (PTH (1-34)) incorporated into a gallic acid-grafted gelatin injectable hydrogel (GLP hydrogel). We show that the GLP hydrogel can form in situ and without affecting knee motion after intra-articular injection in mice. We demonstrate controlled, sustained release of PTH (1-34) from the GLP hydrogel. We find that the GLP hydrogel promotes ATDC5 cell proliferation and protects the IL-1β-induced ATDC5 cells from further OA progression by regulating the PI3K/Akt signaling pathway. Further, we show that intra-articular injection of hydrogels into an OA-induced mouse model promotes glycosaminoglycans synthesis and protects the cartilage from degradation, supporting the potential of this biomaterial for OA treatment.

Figures
Products
我们的 Cookie 政策

我们使用 Cookies 和类似技术以提高网站的性能和提升您的浏览体验，部分功能也使用 Cookies 帮助我们更好地理解您的需求，为您提供相关的服务。 如果您有任何关于我们如何处理您个人信息的疑问，请阅读我们的《隐私声明》。

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z