2. Academic Validation
  3. Electroacupuncture-Modulated Extracellular ATP Levels in Prefrontal Cortex Ameliorated Depressive-like Behavior of Maternal Separation Rats

Electroacupuncture-Modulated Extracellular ATP Levels in Prefrontal Cortex Ameliorated Depressive-like Behavior of Maternal Separation Rats

  • Behav Brain Res. 2023 Jun 22;114548. doi: 10.1016/j.bbr.2023.114548.
Yuanjia Zheng 1,  Lingyun Pan 2,  Jiang He 3,  Jinglan Yan 4,  Yucen Xia 4,  Chuqi Lin 2,  Xiuyun Chen 2,  Qianyi Zhao 2,  Qiuxiang Zeng 2,  Maidinaimu Julikezi 2,  Xinyue Lin 2,  Kaixin Li 4,  Yu Bu 4,  Yujing Fan 5,  Lin Yao 4,  Meng Zhang 4,  Yongjun Chen 6
Affiliations

Affiliations

  • 1 South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China; Research Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, China.
  • 2 South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • 3 Acupuncture and moxibustion and tuina college, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
  • 4 Research Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, China.
  • 5 School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
  • 6 South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China; Research Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, China; Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, Guangzhou, China. Electronic address: chyj417@126.com.
PMID: 37355234 DOI: 10.1016/j.bbr.2023.114548
Abstract

Maternal separation (MS) is a type of early-life stress that has been linked to neuropsychiatric disorders, especially depression. Increasing evidence indicates that the adenosine triphosphate (ATP) level in the prefrontal cortex (PFC) is involved in the pathophysiology of depression. To investigate the potential relationship between ATP in PFC and antidepressant effects of electroacupuncture (EA) treatment, we assessed genes involved in ATP biosynthesis as well as the extracellular ATP levels in a rat model exposed to neonatal MS. Our results demonstrated that reduced expression of ABCG2 (an ATP-binding cassette protein) and ATP levels in the PFC of depressive-like rats exposed to MS can be attenuated by EA stimulus at the Baihui (GV20) and Yintang (GV29) acupoints. Moreover, the antidepressant effect of EA treatment was blocked by administration of suramin, a broad purinergic P2 receptor antagonist. Together, these results suggested that electroacupuncture may be able to modulate extracellular ATP levels in the PFC of depressive-like MS rats, potentially contributing to its antidepressant effects.

Keywords

ATP; Baihui; Depressive-like behaviors; Electroacupuncture; Maternal separation; Yintang.

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