2. Academic Validation
  3. Pimaric acid reduces vasoconstriction via BKCa channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles

Pimaric acid reduces vasoconstriction via BKCa channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles

  • J Pharmacol Sci. 2023 Oct;153(2):84-88. doi: 10.1016/j.jphs.2023.08.001.
Masashi Ishida 1,  Aya Yamamura 2,  Moe Fujiwara 1,  Taiki Amano 1,  Mina Ota 1,  Yukari Hikawa 1,  Rubii Kondo 1,  Yoshiaki Suzuki 1,  Yuji Imaizumi 1,  Hisao Yamamura 3
Affiliations

Affiliations

  • 1 Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori Mizuhoku, Nagoya 467-8603, Japan.
  • 2 Department of Physiology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan.
  • 3 Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabedori Mizuhoku, Nagoya 467-8603, Japan. Electronic address: yamamura@phar.nagoya-cu.ac.jp.
PMID: 37640473 DOI: 10.1016/j.jphs.2023.08.001
Abstract

Pulmonary vessels play a pivotal role in oxygen circulation. We previously demonstrated that pimaric acid (PiMA) activated large-conductance CA2+-activated K+ (BKCA) channels and inhibited voltage-dependent CA2+ channels (VDCCs). In the present study, PiMA attenuated vasoconstriction induced by high K+ or endothelin-1 in rat pulmonary arterial smooth muscles (PASMs). PiMA also reduced high K+-induced cytosolic [CA2+] increase in PASM cells. PiMA increased BKCA currents and decreased VDCC currents. BKCA channels and VDCCs were formed by the α/β1 and α1C/α1D/β2/β3 subunits, respectively. These results indicate that PiMA induces vasorelaxation through the dual effects of BKCA channel activation and VDCC inhibition in PASMs.

Keywords

Ion channel; Pimaric acid; Pulmonary artery.

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