EML4-ALK fusions drive lung adeno-to-squamous transition through JAK-STAT activation

Affiliations

• 1 State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences , Shanghai, China.
• 2 University of Chinese Academy of Sciences , Beijing, China.
• 3 Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
• 4 Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
• 5 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
• 6 Department of Medical Oncology, Hunan Cancer Hospital, Central South University, Changsha, China.
• 7 Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
• 8 Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York University Langone Health , New York, NY, USA.
• 9 School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences , Hangzhou, China.
• 10 Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University , Shanghai, China.
• 11 State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center , Guangzhou, China.
• 12 University of Edinburgh Institute, Zhejiang University , Haining, China.
• 13 Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
• 14 Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Institute of Early Life Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China.
• 15 State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences , Shanghai, China.
• 16 School of Life Science and Technology, Shanghai Tech University , Shanghai, China.
• 17 Division of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
• 18 Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• 19 Ministry of Education Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, Jinan University , Guangzhou, China.
• # Contributed equally.