2. Academic Validation
  3. Palmatine Alleviates Particulate Matter-Induced Acute Lung Injury by Inhibiting Pyroptosis via Activating the Nrf2-Related Pathway

Palmatine Alleviates Particulate Matter-Induced Acute Lung Injury by Inhibiting Pyroptosis via Activating the Nrf2-Related Pathway

  • Inflammation. 2024 Apr 10. doi: 10.1007/s10753-024-02009-2.
Hao Zuo 1 2,  Wanting Zhou 1 2,  Yijing Chen 1 2,  Binqian Zhou 1 2,  Zhengkai Wang 1 2 3,  Shuai Huang 1 2,  Tahereh Alinejad 4,  Chengshui Chen 5 6 7
Affiliations

Affiliations

  • 1 Key Laboratory of Interventional Pulmonology of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China.
  • 2 Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
  • 3 Department of Pulmonary and Critical Care Medicine, the, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 324000, China.
  • 4 Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Institute of Cell Growth Factor, and Brain Health), Wenzhou Medical University, VisionWenzhou, China.
  • 5 Key Laboratory of Interventional Pulmonology of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China. chenchengshui@wmu.edu.cn.
  • 6 Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. chenchengshui@wmu.edu.cn.
  • 7 Department of Pulmonary and Critical Care Medicine, the, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 324000, China. chenchengshui@wmu.edu.cn.
PMID: 38598115 DOI: 10.1007/s10753-024-02009-2
Abstract

Particulate matter (PM) induces and enhances oxidative stress and inflammation, leading to a variety of respiratory diseases, including acute lung injury. Exploring new treatments for PM-induced lung injury has long been of interest to researchers. Palmatine (PAL) is a natural extract derived from Plants that has been reported in many studies to alleviate inflammatory diseases. Our study was designed to explore whether PAL can alleviate acute lung injury caused by PM. The acute lung injury model was established by instilling PM (4 mg/kg) into the airway of mice, and PAL (50 mg/kg and 100 m/kg) was administrated orally as the treatment groups. The effect and mechanism of PAL treatment were examined by immunofluorescence, immunohistochemistry, Western Blotting, ELISA, and other experiments. The results showed that oral administration of PAL (50 mg/kg and 100 m/kg) could significantly alleviate lung inflammation and acute lung injury caused by PM. In terms of mechanism, we found that PAL (50 mg/kg) exerts anti-inflammatory and anti-damage effects mainly by enhancing the activation of the Nrf2-related antioxidant pathway and inhibiting the activation of the NLRP3-related Pyroptosis pathway in mice. These mechanisms have also been verified in our cell experiments. Further cell experiments showed that PAL may reduce intracellular Reactive Oxygen Species (ROS) by activating Nrf2-related pathways, thereby inhibiting the activation of NLRP3-related Pyroptosis pathway induced by PM in Beas-2B cell. Our study suggests that PAL can be a new option for PM-induced acute lung injury.

Keywords

Nrf2; Palmatine; a cute lung injury; particulate matter; pyroptosis.

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