2. Academic Validation
  3. YTHDF1's grip on CRC vasculature: insights into LINC01106 and miR-449b-5p-VEGFA axis

YTHDF1's grip on CRC vasculature: insights into LINC01106 and miR-449b-5p-VEGFA axis

  • Cancer Cell Int. 2024 Jun 4;24(1):195. doi: 10.1186/s12935-024-03360-y.
Rui-Ting Ma 1 2,  Yuanyuan Wang 1,  Feng Ji 1,  Jian-Nan Chen 1,  Tian-Jun Wang 3,  Yan Liu 2,  Ming-Xing Hou 4,  Zhi-Gang Guo 5 6
Affiliations

Affiliations

  • 1 Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, 210023, China.
  • 2 The Affiliated Hospital of Inner Mongolia Medical University, No.1, North Channel Road, Huimin District, Hohhot, 010050, China.
  • 3 Nanjing Medical University, Nanjing, Jiangsu, 210097, China.
  • 4 The Affiliated Hospital of Inner Mongolia Medical University, No.1, North Channel Road, Huimin District, Hohhot, 010050, China. houmingxingfy@126.com.
  • 5 Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, 210023, China. guo@njnu.edu.cn.
  • 6 The Academy of Life Sciences, Nanjing Normal University, Nanjing, 210097, China. guo@njnu.edu.cn.
PMID: 38835070 DOI: 10.1186/s12935-024-03360-y
Abstract

Background: Investigating the unexplored territory of lncRNA m6A modification in colorectal Cancer (CRC) vasculature, this study focuses on LINC01106 and YTHDF1.

Methods: Clinical assessments reveal upregulated LINC01106 promoting vascular generation via the miR-449b-5p-VEGFA pathway.

Results: YTHDF1, elevated in CRC tissues, emerges as an adverse prognostic factor. Functional experiments showcase YTHDF1's inhibitory effects on CRC cell dynamics. Mechanistically, Me-CLIP identifies m6A-modified LINC01106, validated as a YTHDF1 target through Me-RIP.

Conclusions: This study sheds LIGHT on the YTHDF1-mediated m6A modification of LINC01106, presenting it as a key player in suppressing CRC vascular generation.

Keywords

Colorectal cancer; Linc01106; Mir-449b-5p; Vascular generation; Ythdf1; m6a modification.

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