2. Academic Validation
  3. Isorhapontigenin delays senescence and matrix degradation of nucleus pulposus cells via PI3K/AKT/mTOR-mediated autophagy pathway in vitro and alleviates intervertebral disc degeneration in vivo

Isorhapontigenin delays senescence and matrix degradation of nucleus pulposus cells via PI3K/AKT/mTOR-mediated autophagy pathway in vitro and alleviates intervertebral disc degeneration in vivo

  • Int Immunopharmacol. 2024 Sep 30:139:112717. doi: 10.1016/j.intimp.2024.112717.
Ze Wang 1,  Jiawei Ma 1,  Yun Sun 1,  Zebin Jin 1,  Rukang Zheng 1,  Yuanyuan Li 2,  Heng Yu 1,  Haobo Ye 1,  Yaosen Wu 3,  Xinjiang Ge 4,  Zexin Chen 5
Affiliations

Affiliations

  • 1 Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China; Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou, Zhejiang Province, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
  • 2 Aksu District People's Hospital, Aksu, Xinjiang, China.
  • 3 Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
  • 4 Aksu District People's Hospital, Aksu, Xinjiang, China. Electronic address: gexinjiang2003@163.com.
  • 5 Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China. Electronic address: wmuczx@wmu.edu.cn.
PMID: 39067404 DOI: 10.1016/j.intimp.2024.112717
Abstract

Intervertebral disc degeneration (IVDD), a common degenerative disc disease, is a major etiological factor for back pain, affecting a significant number of middle-aged and elderly individuals worldwide. Thus, IVDD is a major socio-economic burden. The factors contributing to the complex IVDD etiology, which has not been elucidated, include inflammation, oxidative stress, and natural aging. In particular, inflammation and aging of nucleus pulposus cells are considered primary pathogenic factors. Isorhapontigenin (ISO) is a polyphenolic compound commonly found in traditional Chinese herbs and grapes. We have demonstrated that ISO exerts anti-inflammatory and Anti-aging effects and mitigates extracellular matrix (ECM) degradation. In this study, in vitro experiments revealed that, ISO delays aging and ECM degradation by promoting PI3K/Akt/mTOR-mediated Autophagy. Meanwhile, in vivo experiments affirmed that ISO delays the progression of IVDD.

Keywords

Autophagy; ECM; Intervertebral disc degeneration; Isorhapontigenin; PI3K/AKT; Senescence.

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