2. Academic Validation
  3. Regulation of cancer cell ferroptosis by PTRF/Cavin-1

Regulation of cancer cell ferroptosis by PTRF/Cavin-1

  • Free Radic Res. 2024 May-Jun;58(6-7):417-429. doi: 10.1080/10715762.2024.2386457.
Hui Xiang 1 2 3,  Miao Wang 4,  Yi-Fang Chen 1 2,  Hao-Ming Wu 5,  Ming-Ge Li 1 2 3,  Lei Guo 1 2 6,  Ying-Yi Zhang 7 8,  He-Zhe Lu 1 2 3
Affiliations

Affiliations

  • 1 State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
  • 2 Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
  • 3 University of Chinese Academy of Sciences, Beijing, China.
  • 4 Key Laboratory of Aging and Cancer Biology of Zhejiang Province, Hangzhou Normal University School of Basic Medical Sciences, Hangzhou, China.
  • 5 Markey Cancer Center, University of Kentucky, Lexington, KY, USA.
  • 6 Life Science and Medicine, University of Science and Technology of China, Hefei, China.
  • 7 Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada.
  • 8 Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
PMID: 39079051 DOI: 10.1080/10715762.2024.2386457
Abstract

Ovarian Cancer, marked by high rate of recurrence, novel therapeutic strategies are needed to improve patient outcome. One of the potential strategies is inducing Ferroptosis in ovarian Cancer cells. Ferroptosis is an iron-dependent, lipid peroxidation-driven mode of cell death primarily occurring on the cell membrane. PTRF, an integral component of the caveolae structures located on the cell membrane, is involved in a multitude of physiological processes, including but not limited to, endocytosis, signal transduction, and lipid metabolism. This study elucidates the relationship between PTRF and Ferroptosis in ovarian Cancer, offering a fresh perspective for the development of new therapeutic strategies. We knocked down PTRF employing siRNA in the ovarian Cancer cell lines HEY and SKOV3, following which we stimulated Ferroptosis with Erastin (Era). Our research indicates that the lack of PTRF sensitizes Cancer cells to Ferroptosis, likely by altering membrane stability and tension, thereby affecting signal pathways related to Ferroptosis, such as lipid and atherosclerosis, fluid shear stress, and atherosclerosis. Our findings provide new insights for developing new treatments for ovarian Cancer.

Keywords

Ferroptosis; PTRF; lipid transport; metabolome; transcriptome.

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