1. Academic Validation
  2. Daphnetin ameliorates diabetic cardiomyopathy by regulating inflammation and endoplasmic reticulum stress-induced apoptosis

Daphnetin ameliorates diabetic cardiomyopathy by regulating inflammation and endoplasmic reticulum stress-induced apoptosis

  • Exp Anim. 2024 Aug 8. doi: 10.1538/expanim.24-0027.
Xiaolong Zhao 1 Longqi Shang 2 Chunjian Shen 3
Affiliations

Affiliations

  • 1 Dalian Medical University.
  • 2 Department of Nursing, The Second Affiliated Hospital of Shenyang Medical College.
  • 3 Department of Cardiothoracic Surgery, The Fourth People's Hospital of Shenyang.
Abstract

Daphnetin has been demonstrated to exert beneficial effects on diabetes mellitus and renal complications. However, the role and molecular mechanism of daphnetin in diabetic cardiomyopathy (DCM) remain unclear. In this study, rats were injected with streptozotocin (STZ) to induce diabetes. The diabetic rats were then administered daphnetin (1 and 4 mg/kg) or dimethyl sulfoxide (DMSO) daily for 12 weeks. The results demonstrated that the diabetic rats exhibited elevated blood glucose levels, which were dose-dependently ameliorated by daphnetin. At 13 weeks following STZ injection, the rats exhibited typical diabetic signs, cardiac dysfunction, and evident pathological alterations in myocardial tissues. The administration of daphnetin to diabetic rats resulted in improvement in cardiac function, reductions in myocardial injury biomarkers, and the inhibition of myocardial fibrosis. Furthermore, daphnetin treatment suppressed inflammation and endoplasmic reticulum stress-induced Apoptosis in a dose-dependent manner. Additionally, daphnetin exhibited partial blockade of the activation of mitogen-activated protein kinase pathways induced by diabetes. These findings indicate that daphnetin may be a promising therapeutic agent for the treatment of DCM.

Keywords

daphnetin; diabetic cardiomyopathy; endoplasmic reticulum stress; fibrosis; mitogen-activated protein kinase pathways.

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