1. Academic Validation
  2. ShSPI Inhibits Thrombosis Formation and Ischemic Stroke In Vivo

ShSPI Inhibits Thrombosis Formation and Ischemic Stroke In Vivo

  • Int J Mol Sci. 2024 Aug 19;25(16):9003. doi: 10.3390/ijms25169003.
Ning Luan 1 Han Cao 1 Yunfei Wang 1 Haihao Zhang 1 Kangyang Lin 1 Jingping Hu 1 Mingqiang Rong 2 Cunbao Liu 1
Affiliations

Affiliations

  • 1 Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China.
  • 2 National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Abstract

Thrombotic diseases, emerging as a global public health hazard with high mortality and disability rates, pose a significant threat to human health and longevity. Although current antithrombotic therapies are effective in treating these conditions, they often carry a substantial risk of bleeding, highlighting the urgent need for safer therapeutic alternatives. Recent evidence has increasingly pointed to a connection between Elastase activity and thrombosis. In the current study, we investigated the antithrombotic effects of ShSPI, an Elastase Inhibitor peptide derived from the venom of Scolopendra hainanum. Results showed that ShSPI significantly attenuated carrageenan-induced thrombosis in vivo. Furthermore, ShSPI effectively inhibited the carrageenan-induced decrease in serum superoxide dismutase (SOD) activity and increase in prothrombin time, fibrinogen level, and endothelial nitric oxide synthase (eNOS) activity. In addition, ShSPI reduced intracerebral thrombosis and improved functional outcomes following ischemic stroke in a transient middle cerebral artery occlusion (tMCAO) mouse model. Collectively, these findings suggest that ShSPI is a promising candidate for the development of novel thrombotic therapies.

Keywords

ShSPI; elastase inhibitor; ischemic stroke; thrombosis; thrombotic diseases.

Figures
Products
我们的 Cookie 政策

我们使用 Cookies 和类似技术以提高网站的性能和提升您的浏览体验,部分功能也使用 Cookies 帮助我们更好地理解您的需求,为您提供相关的服务。 如果您有任何关于我们如何处理您个人信息的疑问,请阅读我们的《隐私声明》