2. Academic Validation
  3. PI4KB is an essential host factor for duck hepatitis a virus 1 replication and translation

PI4KB is an essential host factor for duck hepatitis a virus 1 replication and translation

  • Int J Biol Macromol. 2024 Nov;281(Pt 3):136480. doi: 10.1016/j.ijbiomac.2024.136480.
Xinhong Li 1,  Mingshu Wang 1,  Anchun Cheng 2,  Wei Zhang 3,  Qiao Yang 1,  Bin Tian 1,  Xumin Ou 1,  Di Sun 1,  Yu He 1,  Xinxin Zhao 1,  Ying Wu 1,  Shaqiu Zhang 1,  Juan Huang 1,  Zhen Wu 1,  Yanling Yu 4,  Ling Zhang 4,  Dekang Zhu 5,  Renyong Jia 1,  Mafeng Liu 1,  Shun Chen 1
Affiliations

Affiliations

  • 1 Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu 611130, China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, China; International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu 611130, China.; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu 611130, China.; Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
  • 2 Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu 611130, China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, China; International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu 611130, China.; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu 611130, China.; Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China. Electronic address: chenganchun@vip.163.com.
  • 3 Sinopharm Yangzhou VAC Biological Engineering Co., Ltd., Yangzhou 225100, China.
  • 4 Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu 611130, China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, China; International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu 611130, China.
  • 5 Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, China; International Joint Research Center for Animal Disease Prevention and Control of Sichuan Province, Chengdu 611130, China.; Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu 611130, China.; Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
PMID: 39393728 DOI: 10.1016/j.ijbiomac.2024.136480
Abstract

Duck hepatitis A virus 1 (DHAV-1) is one of the most serious pathogens endangering the duck industry. Phosphatidylinositol 4-kinases (PI4Ks) are important for viral replication, and different viruses have different strategies to hijack PI4Ks. To date, few studies have investigated the DHAV-1 life cycle; thus, whether PI4Ks are required for DHAV-1 replication has not been reported. In this study, we found that the PI4KB protein, a PI4K, promoted the replication and translation of DHAV-1, and the 2A2, 2C, 2BC, 3A, 3AB, 3D, and 3CD proteins of DHAV-1 were able to interact with the PI4KB protein. Amino acids 101-120 of the 2A2 protein is the region where the 2A2 protein interacts with the PI4KB protein.

Keywords

2A2 protein; Duck hepatitis A virus 1; Phosphatidylinositol 4-kinase beta protein.

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