2. Academic Validation
  3. Water pollutant cadmium-induced intestinal inflammation in Eriocheir sinensis and potential therapeutic drugs

Water pollutant cadmium-induced intestinal inflammation in Eriocheir sinensis and potential therapeutic drugs

  • Sci Total Environ. 2024 Dec 10:955:177132. doi: 10.1016/j.scitotenv.2024.177132.
Yana Cheng 1,  Chao Li 2,  Yue Chen 1,  Huan Liu 3,  Haifu Wan 3,  Xianjiang Kang 4,  Shuai Guo 5
Affiliations

Affiliations

  • 1 School of Life Sciences, Hebei University, Baoding, Hebei 071002, China.
  • 2 School of Life Sciences, Hebei University, Baoding, Hebei 071002, China; Institute of Life Sciences and Green Development, Hebei University, Baoding, Hebei 071002, China; Comprehensive Experimental Center, Hebei University, Baoding, Hebei 071002, China.
  • 3 School of Life Sciences, Hebei University, Baoding, Hebei 071002, China; Collaborative Innovation Center for Baiyangdian Basin Ecological Protection and Beijing-Tianjin-Hebei Sustainable Development, Hebei University, Baoding, Hebei 071002, China; Institute of Life Sciences and Green Development, Hebei University, Baoding, Hebei 071002, China.
  • 4 School of Life Sciences, Hebei University, Baoding, Hebei 071002, China; Collaborative Innovation Center for Baiyangdian Basin Ecological Protection and Beijing-Tianjin-Hebei Sustainable Development, Hebei University, Baoding, Hebei 071002, China; Institute of Life Sciences and Green Development, Hebei University, Baoding, Hebei 071002, China. Electronic address: xjkang@hbu.edu.cn.
  • 5 School of Life Sciences, Hebei University, Baoding, Hebei 071002, China; Collaborative Innovation Center for Baiyangdian Basin Ecological Protection and Beijing-Tianjin-Hebei Sustainable Development, Hebei University, Baoding, Hebei 071002, China; Institute of Life Sciences and Green Development, Hebei University, Baoding, Hebei 071002, China. Electronic address: guoshuai@hbu.edu.cn.
PMID: 39442721 DOI: 10.1016/j.scitotenv.2024.177132
Abstract

Objective: Eriocheir sinensis is a significant crustacean in freshwater aquaculture. However, this industry is vulnerable to diseases, including intestinal inflammation. Cadmium (Cd) is a water pollutant that exacerbates intestinal inflammation in Eriocheir sinensis. This study aimed to investigate the mechanisms of Cd-induced intestinal inflammation in Eriocheir sinensis and to identify potential therapeutic agents.

Methods: Histology, Enzyme activity, and gene expression detection were combined to investigate the promoting effect of Cd on the exacerbation of intestinal inflammation in Eriocheir sinensis. Transcriptome Sequencing was performed to analyze the critical signaling pathways regulating intestinal inflammation in Eriocheir sinensis.

Results: Transcriptome analysis confirmed that the Toll-like Receptor pathway is critical in this process. TLR4-IN-C34, a specific inhibitor of TLR4, was identified as a potential treatment for intestinal inflammation. In vivo results demonstrated that TLR4-IN-C34 effectively reduced the severity of Cd-induced intestinal inflammation in Eriocheir sinensis. The tissue morphology of the intestine, gills, and hepatopancreas of Eriocheir sinensis improved, showing a significant decrease in inflammatory factors and apoptotic genes, along with enhanced antioxidant activity.

Conclusions: In conclusion, this study indicates that the water pollutant Cd exacerbates intestinal inflammation in Eriocheir sinensis, and TLR4-IN-C34 regulates the Toll-like Receptor pathway in treating intestinal inflammation. This research provides valuable insights into the management of intestinal inflammation and the sustainable cultivation of Eriocheir sinensis.

Keywords

Aquaculture; Eriocheir sinensis; Intestinal inflammation; TLR pathway; Water pollutant Cd.

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