Dextran sulfate sodium salt (MW 5000)  (Synonyms: 硫酸葡聚糖钠盐 (MW 5000); DSS (MW 5000); DXS (MW 5000))

Dextran sulfate sodium salt (DSS) (MW 5000) is a polymer of dehydrated glucose with a molecular weight of approximately 5000. Dextran sulfate sodium salt (DSS) with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 5000) is an inhibitor of complement and coagulation pathways, and belongs to the glycosaminoglycans (GAG) family. Dextran sulfate sodium salt (MW 5000) acts as an anticoagulant, antiviral, and anti-lipemic agent. Dextran sulfate sodium salt (DSS) stops HIV-1 virus adsorption to host cells. Dextran sulfate sodium salt (MW 5000) prevents NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 5000) inhibits instant blood-mediated inflammatory reaction (IBMIR)^{[1][2][3][4][5]}.

凝血功能研究:
Dextran sulfate sodium salt (MW 5000) 可增强 C1 抑制剂对 FXIa 的作用，加速抗凝血酶和肝素辅因子 II 对凝血酶的抑制。
Dextran sulfate sodium salt (MW 5000) (0.01-1 mg/mL) 在人胰岛与 ABO 相容血液接触时，可抑制宏观凝血，消除血小板消耗，并完全阻断 C3a、FXIa-抗凝血酶和凝血酶-抗凝血酶的产生^[1]。

抗病毒活性:
Dextran sulfate sodium salt (MW 5000) (25 μg/mL；24 小时) 可完全保护 MT-4 细胞免受 HIV-1 诱导的细胞致病性^[2]。

其他活性:
Dextran sulfate sodium salt (MW 5000) 可用 2-氨基吡啶标记 (产生吡啶氨基-DSS 或 PA-DSS)，并用于检查其在 Caco-2 细胞中的代谢。PA-DSS (MW 5000) (3%；24 小时) 迅速抑制 Caco-2 细胞的能量代谢^[3]。
Dextran sulfate sodium salt (MW 5000) (0-25 mg/mL，6 小时) 保护人成肌细胞免受 NK 细胞介导的杀伤^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dextran sulfate sodium salt (MW 5000) (5 mg/mL，200 μL，在再灌注前立即局部输注到缺血主动脉段) 可抑制补体活化，从而减少大鼠肾下主动脉钳夹模型中缺血和再灌注后的内皮损伤^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

5000(Average)

9011-18-1

固体

Off-white to light yellow

硫酸葡聚糖；硫酸葡聚糖钠；葡聚糖硫酸酯钠；葡聚糖硫酸氢钠；糖酐酯

Room temperature in continental US; may vary elsewhere.

Store at room temperature, keep dry and cool

• [1]. Johansson H, et al. Low molecular weight dextran sulfate: a strong candidate drug to block IBMIR in clinical islet transplantation. Am J Transplant. 2006 Feb;6(2):305-12.  [Content Brief]

  [2]. Baba M, et al. Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6132-6.  [Content Brief]

  [3]. Araki Y, et al. Dextran sulfate sodium administered orally is depolymerized in the stomach and induces cell cycle arrest plus apoptosis in the colon in early mouse colitis. Oncol Rep. 2012 Nov;28(5):1597-605.  [Content Brief]

  [4]. Laumonier T,et al. Low molecular weight dextran sulfate binds to human myoblasts and improves their survival after transplantation in mice. Cell Transplant. 2013;22(7):1213-26.  [Content Brief]

  [5]. Banz Y, et al. Dextran sulfate modulates MAP kinase signaling and reduces endothelial injury in a rat aortic clamping model. J Vasc Surg. 2009 Jul;50(1):161-70.  [Content Brief]