2. Academic Validation
  3. Distribution and impact of p16INK4A+ senescent cells in elderly tissues: a focus on senescent immune cell and epithelial dysfunction

Distribution and impact of p16INK4A+ senescent cells in elderly tissues: a focus on senescent immune cell and epithelial dysfunction

  • Exp Mol Med. 2024 Dec;56(12):2631-2641. doi: 10.1038/s12276-024-01354-4.
Soon Sang Park # 1 2,  Young-Kyoung Lee # 1 2,  Young Hwa Kim # 1,  So Hyun Park 3,  Hee Young Kang 1 4,  Jin Cheol Kim 1 4,  Dong Jun Kim 2,  Su Bin Lim 1 2 5,  Gyesoon Yoon 1 2 5,  Jang-Hee Kim 3,  Yong Won Choi 6 7,  Tae Jun Park 8 9 10
Affiliations

Affiliations

  • 1 Inflammaging Translational Research Center, Ajou University Medical Center, Suwon, Korea.
  • 2 Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, Korea.
  • 3 Department of Pathology, Ajou University School of Medicine, Suwon, Korea.
  • 4 Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.
  • 5 Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Korea.
  • 6 Inflammaging Translational Research Center, Ajou University Medical Center, Suwon, Korea. dreamliebe@daum.net.
  • 7 Department of Hematology and Oncology, Ajou University School of Medicine, Suwon, Korea. dreamliebe@daum.net.
  • 8 Inflammaging Translational Research Center, Ajou University Medical Center, Suwon, Korea. park64@ajou.ac.kr.
  • 9 Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, Korea. park64@ajou.ac.kr.
  • 10 Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Korea. park64@ajou.ac.kr.
  • # Contributed equally.
PMID: 39617789 DOI: 10.1038/s12276-024-01354-4
Abstract

Cellular senescence, recognized as a key hallmark of aging, leads to the accumulation of senescent cells in various tissues over time. While the detrimental effects of these cells on age-related pathological conditions are well-documented, there is still limited information about how senescent cells are distributed in normal tissues of both young and aged organs. Our research indicates that fully senescent p16INK4A+ cells are rarely identified in the parenchyma of organic tissues and in the stromal cells crucial for structural maintenance, such as fibroblasts and smooth muscle cells. Instead, p16INK4A+ cells are more commonly found in immune cells, whether they reside in the organ or are infiltrating. Notably, p16INK4A+ senescent T cells have been observed to induce Apoptosis and inflammation in colonic epithelial cells through Granzyme A-PARs signaling, compromising the integrity of the epithelial lining. This study showed that the senescence of immune cells could affect the phenotypical change of the parenchymal cells in the elderly and suggests that targeting immunosenescence might be a strategy to control functional decline in this population.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z