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  3. E3 ubiquitination ligase XIAP lightens diabetes-induced cognitive impairment by inactivating TXNIP-ERS-mediated neuronal injury

E3 ubiquitination ligase XIAP lightens diabetes-induced cognitive impairment by inactivating TXNIP-ERS-mediated neuronal injury

  • Kaohsiung J Med Sci. 2025 Jan;41(1):e12913. doi: 10.1002/kjm2.12913.
Qin Zhang 1,  Hai-Jin Huang 1,  Jing-Ling Zhang 1,  Ying Tian 1,  Ying Hu 2 3 4
Affiliations

Affiliations

  • 1 Department of Anesthesiology and Operative Medicine, Medical Center of Anesthesiology and Pain, the 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, PR China.
  • 2 Department of Endocrinology and Metabolism, the 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, PR China.
  • 3 Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang, Jiangxi Province, PR China.
  • 4 Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang, Jiangxi Province, PR China.
PMID: 39629879 DOI: 10.1002/kjm2.12913
Abstract

Diabetes-induced cognitive dysfunction (DCD) is a neurological disorder associated with diabetes, characterized by cognitive impairment driven by neuronal injury from chronic high glucose (HG) exposure. This study aims to elucidate the role and mechanisms of the X-linked inhibitor of Apoptosis protein (XIAP)/thioredoxin-interacting protein (TXNIP) in hippocampal neuron cell death and cognitive function within DCD models. A diabetic rat model was established using a high-fat/sucrose diet and streptozotocin injection. Primary hippocampal neurons were stimulated with HG to mimic diabetic conditions. Cognitive and memory functions were assessed using the Morris water maze (MWM) and novel object recognition test (ORT).

Keywords

TXNIP; XIAP; diabetes‐induced cognitive dysfunction; endoplasmic reticulum stress.

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