2. Academic Validation
  3. Biocompatible ionized air alleviates rat osteoarthritis by modulating polarization from M1 to M2 macrophages

Biocompatible ionized air alleviates rat osteoarthritis by modulating polarization from M1 to M2 macrophages

  • Sci Rep. 2024 Dec 30;14(1):31901. doi: 10.1038/s41598-024-83198-6.
Haoran Yu # 1 2,  Chengbiao Ding # 3,  Zhongyao Hu # 1 2,  Qi Liu 4,  Xuesong Gu 5,  Junyan He 1 2,  Yiqun Yan 1 2,  Shenrui Yu 5,  Lin Gao 6,  Wendan Cheng 7 8,  Zhengwei Wu 9,  Juehua Jing 10 11
Affiliations

Affiliations

  • 1 Department of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230000, China.
  • 2 Institute of Orthopedics, Research Center for Translational Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230000, China.
  • 3 Department of Rehabilitation Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230000, China.
  • 4 School of Nuclear Science and Technology, University of Science and Technology of China, Hefei, 230000, China.
  • 5 The Second Clinical Medical College of Anhui Medical University, Hefei, 230000, China.
  • 6 The First Clinical Medical College of Anhui Medical University, Hefei, 230000, China.
  • 7 Department of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230000, China. sunyccc@126.com.
  • 8 Institute of Orthopedics, Research Center for Translational Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230000, China. sunyccc@126.com.
  • 9 School of Nuclear Science and Technology, University of Science and Technology of China, Hefei, 230000, China. wuzw@ustc.edu.cn.
  • 10 Department of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230000, China. jjhhu@sina.com.
  • 11 Institute of Orthopedics, Research Center for Translational Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230000, China. jjhhu@sina.com.
  • # Contributed equally.
PMID: 39738316 DOI: 10.1038/s41598-024-83198-6
Abstract

The imbalance in the proportion of M1/M2 macrophage polarization is a crucial contributor to the persistent progression of osteoarthritis (OA). This study aimed to evaluate the effects of low-dose biocompatible ionized air (BIA) on macrophage polarization and its subsequent chondroprotective effects, thereby validating the potential of BIA in slowing the progression of OA. In vitro experiments demonstrated that BIA modulates the polarization of M1 macrophages toward the M2 phenotype via the ROS-mediated STAT6 pathway. This shift reduces the expression of pro-inflammatory mediators while increasing the expression of anti-inflammatory mediators and pro-chondrogenic factors, leading to an improved microenvironment surrounding chondrocytes. The direct benefits of this improved microenvironment include enhanced chondrocyte viability, inhibition of Apoptosis, and reduced degradation of the extracellular matrix. In vivo studies in rats showed that BIA inhibited M1 macrophage infiltration in the synovium, upregulated the proportion of M2 macrophages, alleviated cartilage degeneration, and delayed OA progression. This gas-based regulatory strategy may open new avenues for the treatment of OA.

Keywords

Biocompatible ionized air; Macrophages; Osteoarthritis.

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