2. Academic Validation
  3. Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway

Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway

  • Mol Med. 2025 Jan 29;31(1):30. doi: 10.1186/s10020-025-01080-1.
Maoping Cai # 1 2 3,  Shengdong Ge # 4,  Yaying Hong # 4,  Yao Chen 5,  Yang-Zi Ren 6,  Dacai Zhong 3,  Mingkun Chen 2 7,  Yuan Liu 4,  Zhe-Sheng Chen 8,  Ninghan Feng 9 10 11,  Zhanghui Chen 12,  Shan-Chao Zhao 13 14 15 16
Affiliations

Affiliations

  • 1 Department of Urology, The Fifth Affiliated Hospital of Southern Medical University, Guangzhou, 510920, Guangdong, People's Republic of China.
  • 2 The Third Clinical College, Southern Medical University, Guangzhou, 510630, Guangdong, People's Republic of China.
  • 3 Zhanjiang Institute of Clinical Medicine, Central People's Hospital of Zhanjiang, Zhanjiang, 524045, Guangdong, People's Republic of China.
  • 4 Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.
  • 5 College of Pulmonary and Critical Care Medicine, The 8th Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
  • 6 Department of Oncology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, Guangdong, People's Republic of China.
  • 7 Department of Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, Guangdong, People's Republic of China.
  • 8 Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY, 11439, USA.
  • 9 Department of Urology, Jiangnan University Medical Center, Wuxi, 214002, People's Republic of China. fnh888@njmu.edu.cn.
  • 10 Wuxi School of Medicine, Jiangnan University, Wuxi, 214002, People's Republic of China. fnh888@njmu.edu.cn.
  • 11 Department of Urology, Affiliated Wuxi No. 2 Hospital, Nanjing Medical University, Wuxi, 214002, People's Republic of China. fnh888@njmu.edu.cn.
  • 12 Zhanjiang Institute of Clinical Medicine, Central People's Hospital of Zhanjiang, Zhanjiang, 524045, Guangdong, People's Republic of China. zjcell@126.com.
  • 13 Department of Urology, The Fifth Affiliated Hospital of Southern Medical University, Guangzhou, 510920, Guangdong, People's Republic of China. lulululu@smu.edu.cn.
  • 14 The Third Clinical College, Southern Medical University, Guangzhou, 510630, Guangdong, People's Republic of China. lulululu@smu.edu.cn.
  • 15 Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China. lulululu@smu.edu.cn.
  • 16 Department of Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, Guangdong, People's Republic of China. lulululu@smu.edu.cn.
  • # Contributed equally.
PMID: 39881254 DOI: 10.1186/s10020-025-01080-1
Abstract

Prostate Cancer (PCa) is a highly common type of malignancy and affects millions of men in the world since it is easy to recur or emerge therapy resistance. Therefore, it is urgent to find novel treatments for PCa patients. In the current study, we found that tegaserod maleate (TM), an FDA-approved agent, inhibited proliferation, colony formation, migration as well as invasion, caused the arrest of the cell cycle, and promoted Apoptosis of PCa cells in vitro. In addition, TM suppressed the tumor growth in the cell-derived xenograft (CDX) mouse model in vivo. Mechanistically, TM exerted anti-tumor effects via downregulating GLI2, and its downtream targets, thus inhibiting the sonic Hedgehog (SHH) signaling pathway. In brief, our findings demonstrated that TM effectively inhibited the activities of PCa cells by suppressing the SHH signaling pathway and provided a potential new agent for the treatment of PCa.

Keywords

GLI2; Prostate cancer (PCa); Sonic hedgehog (SHH) signaling; Tegaserod maleate (TM); Treatment.

Figures
Products
Inhibitors & Agonists
Other Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z