2. Academic Validation
  3. Undescribed lignans from the resin Styrax tonkinensis and their anti-renal fibrosis activities

Undescribed lignans from the resin Styrax tonkinensis and their anti-renal fibrosis activities

  • Fitoterapia. 2025 Feb 3:182:106413. doi: 10.1016/j.fitote.2025.106413.
Yuan-Cheng Xu 1,  Liu-Yue Chen 1,  Yong-Xian Cheng 2
Affiliations

Affiliations

  • 1 School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.
  • 2 School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Institute for Inheritance-Based Innovation of Chinese Medicine, Marshall Laboratory of Biomedical Engineering, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, China. Electronic address: yxcheng@szu.edu.cn.
PMID: 39909354 DOI: 10.1016/j.fitote.2025.106413
Abstract

Styraxtokisans A - G (1-7), including six enantiomeric pairs of undescribed Lignans (1, 2, 4-7) and a pair of undescribed Phenylpropanoids (3), were isolated from the ethanol extract of the resin Styrax tonkinensis. Comprehensive spectroscopic and computational studies, along with the advanced chemical separation techniques, enabled the confirmation of the structures of these new compounds. The enantiomers of the racemates (1-7) were separated using chiral HPLC. The biological evaluation of these isolates towards anti-renal fibrosis demonstrated that compound 1b could effectively reduce the protein expression levels of fibronectin, collagen I and α-SMA in TGF-β1-induced NRK-52e cells.

Keywords

Lignans; Phenylpropanoids; Renal fibrosis; Styrax tonkinensis.

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