2. Academic Validation
  3. Microneedle Assisted Melittin-Chondroitin Sulfate Administration for the Transdermal Therapy of Rheumatoid Arthritis

Microneedle Assisted Melittin-Chondroitin Sulfate Administration for the Transdermal Therapy of Rheumatoid Arthritis

  • Adv Healthc Mater. 2025 Feb 19:e2400543. doi: 10.1002/adhm.202400543.
Lili Jin 1 2 3,  Zhenhui Wang 2 3,  Cheng Peng 4,  Miao He 2,  Feng Wang 4,  Hongyan He 1 2 3,  Changsheng Liu 1 2
Affiliations

Affiliations

  • 1 Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai, 200237, P. R. China.
  • 2 Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, P. R. China.
  • 3 School of Material Science and Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.
  • 4 The Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Frontiers Science Center of Biomimetic Catalysis, Shanghai Normal University, Shanghai, 200234, P. R. China.
PMID: 39972637 DOI: 10.1002/adhm.202400543
Abstract

Rheumatoid arthritis (RA), a persistent and debilitating chronic disease characterize by joint damage and deformity, significantly impairs the life quality of patients and presents challenges for conventional drug administration due to organ damage and unsatisfactory therapeutic outcomes. To address these challenges, this study introduces an innovative hydrogel cryo-microneedle patch (CMNP)-mediated local administration system, primarily composed of chondroitin sulfate (CS), to deliver the potent anti-inflammatory drug melittin (MEL). This innovative approach not only circumvents organ impairment but also enhances patient compliance. The acute toxicity of MEL is effectively mitigated by electrostatic binding with CS molecules, forming MC complexes that induce Apoptosis in fibroblast-like synoviocytes (FLS). The MC-loaded CMNPs (MC@CCMNPs) exhibit remarkable therapeutic capacity with a notably meliorated joint damage and suppressed arthritis severity in the RA rat model. Therefore, MC@CCMNPs emerge as a promising anti-inflammatory and safe therapy for RA treatment, as well as for Other inflammation related chronic diseases.

Keywords

chondroitin sulphate; melittin; microneedles; rheumatoid arthritis; surface‐enhanced Raman scattering.

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