2. Academic Validation
  3. Ginsenoside CK Promotes Cell Apoptosis via Regulating P53 Signal Pathway in Non-Small Cell Lung Cancer

Ginsenoside CK Promotes Cell Apoptosis via Regulating P53 Signal Pathway in Non-Small Cell Lung Cancer

  • Drug Dev Res. 2025 Apr;86(2):e70050. doi: 10.1002/ddr.70050.
Xinze Liu 1,  Lin Feng 2,  Xin Jin 3,  Kaijing Sun 1,  Ying Sun 4,  Xinmin Wu 5,  Mingjie Xia 6,  Renbo Tan 7,  Hongmei Yang 7,  Guangzhe Li 2,  Wei Wu 1,  Shuang Zu 8,  Anning Li 8,  Changbao Chen 1,  Xilin Wan 1 8
Affiliations

Affiliations

  • 1 Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, China.
  • 2 College of Pharmacy, Changchun University of Chinese Medicine, Changchun, China.
  • 3 Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), Northeast Normal University, Changchun, China.
  • 4 Clinical Laboratory, The Second Hospital of Dalian Medical University, Dalian, China.
  • 5 Department of Neurosurgery, The First Hospital of Jilin University, Changchun, China.
  • 6 Department of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, China.
  • 7 Northeast Asia Institute of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
  • 8 Jilin Aodong Pharmaceutial Group Co., Ltd Post-Doctoral Research Center, Yanbian, China.
PMID: 39991943 DOI: 10.1002/ddr.70050
Abstract

Non-small cell lung Cancer (NSCLC) is a malignant tumor with high morbidity and mortality. Ginsenosides have been shown to have strong antitumor activity, inhibiting tumor cell growth and promoting Apoptosis. In this paper, the effects of ginsenoside CK on the proliferation and Apoptosis of NSCLC 95D and NCI-H460 cells were investigated by CCK8, colony formation assay, flow cytometry, fluorescence staining assay, and Western Blot, and it was found that ginsenoside CK could significantly inhibit the growth and proliferation of non-small cell lung Cancer, and it was also clarified that the mechanism of its action was realized by the mitochondrial Apoptosis pathway. It provides new therapeutic ideas for lung Cancer and Other major tumor diseases.

Keywords

cell apoptosis; cell proliferation; ginsenoside CK; mechanism of action.

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