2. Academic Validation
  3. Eupenifeldin, a novel cytotoxic bistropolone from Eupenicillium brefeldianum

Eupenifeldin, a novel cytotoxic bistropolone from Eupenicillium brefeldianum

  • J Antibiot (Tokyo). 1993 Jul;46(7):1082-8. doi: 10.7164/antibiotics.46.1082.
F Mayerl 1,  Q Gao,  S Huang,  S E Klohr,  J A Matson,  D R Gustavson,  D M Pirnik,  R L Berry,  C Fairchild,  W C Rose
Affiliations

Affiliation

  • 1 Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, Connecticut 06492.
PMID: 8360103 DOI: 10.7164/antibiotics.46.1082
Abstract

Eupenifeldin was isolated from cultures of Eupenicillium brefeldianum ATCC 74184 by extraction and crystallization. The compound was identified as a pentacyclic bistropolone on the basis of spectral data and its complete structure was established by single-crystal X-ray analysis. The compound is cytotoxic against the HCT-116 cell line and has in vivo antitumor activity in the P388 leukemia model.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z