2. Anti-infection Protein Tyrosine Kinase/RTK
  3. Bacterial c-Met/HGFR Antibiotic
  4. Meleagrin

Meleagri 是由青霉属 (Penicillium) 真菌产生的具有抗微生物和抗增殖活性的罗奎福汀 C 衍生生物碱。Meleagrin 是一类 FabI 抑制剂。Meleagri 是一种主要的 c-Met 抑制实体，有助于控制 c-Met 依赖性转移和侵袭性乳腺癌。

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Meleagrin Chemical Structure

Meleagrin Chemical Structure

CAS No. : 71751-77-4

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1 mg ￥2300
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Meleagrin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Meleagrin is a roquefortine C-derived alkaloid produced by fungi of the genus Penicillium and has antimicrobial and anti-proliferative activities. Meleagrin is a class of FabI inhibitor. Meleagrin is a lead c-Met inhibitory entity useful for the control of c-Met-dependent metastatic and invasive breast malignancies[1][2][3].

体外研究
(In Vitro)

Meleagrin inhibits the growth of the human breast cancer cell lines MDA-MB-231, MDA-468, BT-474, SK BR-3, MCF7 and MCF7-dox[3].
Meleagrin causes a dose-dependent inhibition of HGF-induced cell migration, and invasion of breast cancer cell lines[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Meleagrin 相关抗体:
体内研究
(In Vivo)

Meleagrin potently suppresses the invasive triple negative breast tumor cell growth in an orthotopic athymic nude mice model[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

433.46

Formula

C23H23N5O4
CAS 号
性状

固体

颜色

Off-white to light yellow

结构分类
初始来源

marine fungus Emericella dentata Nq45
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥99.0%

COA (278 KB)

产品使用指南 (1538 KB)
参考文献

Meleagrin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Meleagrin71751-77-4Bacterialc-Met/HGFRAntibioticInhibitorinhibitorinhibit

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目录号：
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