2. Anti-infection Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Fungal Apoptosis Phospholipase Reactive Oxygen Species
  4. Melittin free acid

Melittin free acid 是一种由 26 个氨基酸组成的碱性多肽，是蜂毒的主要活性成分。Melittin free acid 是磷脂酶 A2 (PLA2) 的激活剂。Melittin free acid 具有广谱抗真菌活性，MIC 值为 0.4-60 μM。Melittin free acid 通过诱导细胞凋亡、抑制 (1,3)-β-D-葡聚糖合成酶以及参与其他通路等途径抑制真菌生长。

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Custom Peptide Synthesis

Melittin free acid Chemical Structure

Melittin free acid Chemical Structure

CAS No. : 123168-46-7

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Melittin free acid 的其他形式现货产品:

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Melittin free acid 相关抗体

Top Publications Citing Use of Products

    Melittin free acid purchased from MCE. Usage Cited in: J Pharm Pharmacol. 2023 Mar 26;rgad008.  [Abstract]

    Melittin (2.5, 5, 10 μg/mL; 48 h) downregulates the expression of Bcl-2, and increases the levels of the pro-apoptotic molecules Bax and cyt-c, in SW480 cells.

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    Phospholipase A PLD Phospholipase C

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways[1][2].

    体外研究
    (In Vitro)

    Melittin free acid 刺激小鼠纤维细胞 (MC5-5)、人成纤维细胞 (D550)、兔主动脉内皮细胞 (CLO)、大鼠肺型肺泡肺细胞 (L-2) 和兔平滑肌细胞 (R-I) 的前列腺素生物合成[1]。
    Melittin free acid 刺激 MC5-5 细胞磷脂中花生四烯酸的释放[1]。
    Melittin free acid 诱导黄曲霉萌发分生孢子中活性氧的积累[2]。
    Melittin 抑制灰霉菌 MUCL 30158 和 CECT 2100 菌株，IC50 值分别为 3.1 和 24 μM[2]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Melittin free acid 相关抗体:
    体内研究
    (In Vivo)

    Melittin (腹腔内接种) 可增加小鼠外周血中 13,14-dihydro-15-keto-PGE2 的水平[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    2847.45

    Formula

    C131H228N38O32
    CAS 号
    Sequence Shortening

    GIGAVLKVLTTGLPALISWIKRKRQQ
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Melittin free acid 相关分类

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Melittin123168-46-7FungalApoptosisPhospholipaseReactive Oxygen SpeciespolypeptideantifungalapoptosisMC5-5ROSbroad-spectrumInhibitorinhibitorinhibit

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