2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Methapyrilene hydrochloride

Methapyrilene hydrochloride  (Synonyms: Thenylpyramine hydrochloride)

目录号: HY-B1483 纯度: ≥99.0%
COA 产品使用指南

摩尔计算器

Methapyrilene (Thenylpyramine) hydrochloride 是一种口服活性 H1 受体 (H1-receptor antihistamine) 抗组胺剂和吡啶类抗胆碱能剂。Methapyrilene hydrochloride 具有肝毒性，可作为肝毒素在体内引起门脉周围肝坏死。

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Methapyrilene hydrochloride Chemical Structure

Methapyrilene hydrochloride Chemical Structure

CAS No. : 135-23-9

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规格 价格 是否有货 数量
5 mg ￥243
In-stock
10 mg ￥387
In-stock
25 mg ￥765
In-stock
50 mg   询价  
100 mg   询价  

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Other Forms of Methapyrilene hydrochloride:

Methapyrilene hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Methapyrilene (Thenylpyramine) hydrochloride is an orally active H1-receptor antihistamine and an anticholinergic agent of the pyridine chemical class. Methapyrilene hydrochloride has hepatotoxicity and can be used as a hepatotoxin that cause periportal hepatic necrosis in vivo[2]

IC50 & Target[1]

H1 Receptor

 

体外研究
(In Vitro)

Methapyrilene hydrochloride (650 μM) results in a down-regulation of TF and up-regulation of FTL, while the level of HMOX1 is not changed. Additionally, the levels of CD44 and SOX9 proteins and the expression of PROM1 (CD133), hepatic stem cell-associated markers are increased[1].
Methapyrilene hydrochloride (650 μM) decreases CYP2E1, CYP3A4, NR1l3, ALB, mRNA expression and increases CD133 expression[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Methapyrilene hydrochloride 相关抗体:
体内研究
(In Vivo)

Methapyrilene hydrochloride (oral gavage; 40 or 80 mg/kg; 5 days per week; 6 weeks) results in changes in the expression of classic hepatotoxicity-related marker genes and iron homeostasis-related genes, especially a prominent, dose-dependent down-regulation of the transferrin (Tf) gene and an up-regulation of the ferritin, light chain (FTL) gene in rats[1].
Methapyrilene hydrochloride (oral gavage; 150 mg/kg; 3 days) causes periportal liver necrosis at high dosage. Methapyrilene is sufficient to induce liver necrosis, or a subtoxic dose of 50 mg/kg/day[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

297.85

Formula

C14H20ClN3S
CAS 号
性状

固体

颜色

Off-white to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 10 mg/mL (33.57 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3574 mL 16.7870 mL 33.5739 mL
5 mM 0.6715 mL 3.3574 mL 6.7148 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥99.0%

COA (289 KB)

产品使用指南 (1538 KB)
参考文献

Methapyrilene hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3574 mL 16.7870 mL 33.5739 mL 83.9349 mL
5 mM 0.6715 mL 3.3574 mL 6.7148 mL 16.7870 mL
10 mM 0.3357 mL 1.6787 mL 3.3574 mL 8.3935 mL
15 mM 0.2238 mL 1.1191 mL 2.2383 mL 5.5957 mL
20 mM 0.1679 mL 0.8393 mL 1.6787 mL 4.1967 mL
25 mM 0.1343 mL 0.6715 mL 1.3430 mL 3.3574 mL
30 mM 0.1119 mL 0.5596 mL 1.1191 mL 2.7978 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methapyrilene135-23-9ThenylpyramineHistamine ReceptorHepatotoxicity,?periportal hepatic necrosishepatotoxinanticholinergicantihistamineInhibitorinhibitorinhibit

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