2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Methyl azetidine-3-carboxylate hydrochloride

Methyl azetidine-3-carboxylate hydrochloride 

目录号: HY-33615 纯度: 99.66%
COA 产品使用指南 技术支持

Methyl azetidine-3-carboxylate (hydrochloride) 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联活性分子 (ADCs)。Methyl azetidine-3-carboxylate (hydrochloride) 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。

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Methyl azetidine-3-carboxylate hydrochloride Chemical Structure

Methyl azetidine-3-carboxylate hydrochloride Chemical Structure

CAS No. : 100202-39-9

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规格 价格 是否有货 数量
1 g ￥100
In-stock
5 g ￥150
In-stock
10 g ￥240
In-stock
25 g ￥460
In-stock
100 g ￥1457
In-stock
> 100 g   询价  

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Customer Review

Methyl azetidine-3-carboxylate hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 ADC Linker 亚型特异性产品:

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Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Methyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<

IC50 & Target

Non-cleavable Linker

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Methyl azetidine-3-carboxylate hydrochloride 相关抗体:
分子量

151.59

Formula

C5H10ClNO2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (824.59 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 6.5967 mL 32.9837 mL 65.9674 mL
5 mM 1.3193 mL 6.5967 mL 13.1935 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.66%

COA (287 KB) HNMR (223 KB) RP-HPLC (197 KB)

产品使用指南 (1538 KB)
参考文献

Methyl azetidine-3-carboxylate hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.5967 mL 32.9837 mL 65.9674 mL 164.9185 mL
5 mM 1.3193 mL 6.5967 mL 13.1935 mL 32.9837 mL
10 mM 0.6597 mL 3.2984 mL 6.5967 mL 16.4919 mL
15 mM 0.4398 mL 2.1989 mL 4.3978 mL 10.9946 mL
20 mM 0.3298 mL 1.6492 mL 3.2984 mL 8.2459 mL
25 mM 0.2639 mL 1.3193 mL 2.6387 mL 6.5967 mL
30 mM 0.2199 mL 1.0995 mL 2.1989 mL 5.4973 mL
40 mM 0.1649 mL 0.8246 mL 1.6492 mL 4.1230 mL
50 mM 0.1319 mL 0.6597 mL 1.3193 mL 3.2984 mL
60 mM 0.1099 mL 0.5497 mL 1.0995 mL 2.7486 mL
80 mM 0.0825 mL 0.4123 mL 0.8246 mL 2.0615 mL
100 mM 0.0660 mL 0.3298 mL 0.6597 mL 1.6492 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methyl azetidine-3-carboxylate100202-39-9ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Methyl azetidine-3-carboxylate hydrochloride
目录号：
HY-33615
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