2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis Caspase
  4. Microtubule destabilizing agent-2

Microtubule destabilizing agent-2 

目录号: HY-159891
产品使用指南

摩尔计算器

Microtubule destabilizing agent-2 (Compound 21) 是一种口服有效和选择性的靶向微管蛋白的抗肿瘤化合物。Microtubule destabilizing agent-2 可破坏微管蛋白稳定性，抑制微管聚合物。Microtubule destabilizing agent-2 使人肿瘤细胞 G0/G1 期停滞，通过激活 Caspase 级联途径诱导细胞凋亡 (apoptosis)。Microtubule destabilizing agent-2 还具有抗炎活性，在体外能抑制 TNF-α 和 IL-6 产生。Microtubule destabilizing agent-2 可抑制异种移植小鼠的肿瘤生长。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Microtubule destabilizing agent-2 Chemical Structure

Microtubule destabilizing agent-2 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Microtubule destabilizing agent-2 相关抗体

Top Publications Citing Use of Products

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Microtubule destabilizing agent-2 (Compound 21) is an orally active and selective antitumor compound targeting microtubule protein. Microtubule destabilizing agent-2 destabilizes microtubule proteins and inhibits microtubule polymers. Microtubule destabilizing agent-2 arrests the G0/G1 phase in human tumor cells. Microtubule destabilizing agent-2 induces apoptosis by activating the cascade pathway of caspases. Microtubule destabilizing agent-2 has anti-inflammatory activity, as inhibiting TNF-α and IL-6 in vitro. Microtubule destabilizing agent-2 reduces tumors growth in xenograft mice[1].

IC50 & Target[1]

Caspase 3

 

体外研究
(In Vitro)

Microtubule destabilizing agent-2 (48 h) 相较于82.46 μM (MCF-7)、31.27 μM (MDA-MB-231) 的IC50，对人白血病细胞K-562具有选择性抗增殖作用 (IC50: 3.27 μM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Microtubule destabilizing agent-2 相关抗体:
体内研究
(In Vivo)

Microtubule destabilizing agent-2 (20-80 mg/kg，口服， 28天) 在 K562 异种移植小鼠模型中具有中至低度抗癌效果[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: K562 xenograft mouse model[1]
Dosage: 20, 40, 80 mg/kg.
Administration: Oral gavage (p.o.). 5 days a week for four weeks
Result: Showed weak anticancer effect at 20 mg/kg (36 % reduction) and 40 mg/kg (31.68 % reduction), but moderate effect at 80 mg/kg (47 %).
分子量

402.48

Formula

C26H26O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Microtubule destabilizing agent-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Microtubule destabilizing agent-2Microtubule destabilizing agent2Microtubule destabilizing agent 2Microtubule/TubulinApoptosisCaspaseMicrotubule destabilizationAnticancerAnti-inflammatoryXenograftK562Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Microtubule destabilizing agent-2
目录号：
HY-159891
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z