MK2-IN-5 acetate  (Synonyms: Hsp25 kinase inhibitor acetate; Mk2 pseudosubstrate acetate)

MK2-IN-5 (Hsp25 kinase inhibitor) acetate is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 acetate targets the protein interaction domain in the MAPK pathway. MK2-IN-5 acetate inhibits HSP25 and HSP27 phosphorylation^[1][2][3].

MK2-IN-5 acetate (5-10 μM, 2 h) 抑制 TGF-b1 诱导的人瘢痕疙瘩成纤维细胞中结缔组织生长因子和 I 型胶原的表达^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MK2-IN-5 acetate (2 mg/kg Intraperitoneal injection, single dose) 降低呼吸机相关性肺损伤模型中 HSP25 的磷酸化^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1396.68 (free base)

C₆₁H₁₁₃N₂₁O₁₆.xC₂H₄O₂

固体

White to off-white

Lys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala

KKKALNRQLGVAA

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

• [1]. Gaestel M, et al. Peptides as signaling inhibitors for mammalian MAP kinase cascades [J]. Current pharmaceutical design, 2009, 15(21): 2471-2480.  [Content Brief]

  [2]. Damarla M, et al. Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury [J]. PloS one, 2009, 4(2): e4600.  [Content Brief]

  [3]. Lopes L B, et al. Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor [J]. Biochemical and biophysical research communications, 2009, 382(3): 535-539.  [Content Brief]