2. MAPK/ERK Pathway Stem Cell/Wnt Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. ERK JNK p38 MAPK HSP MAPKAPK2 (MK2)
  4. MK2-IN-5

MK2-IN-5  (Synonyms: Hsp25 kinase inhibitor; Mk2 pseudosubstrate)

目录号: HY-P10072
产品使用指南

摩尔计算器

MK2-IN-5 是 Mk2 的假底物 (Ki= 8 μM)。MK2-IN-5 靶向 MAPK 通路中的蛋白相互作用域。MK2-IN-5 抑制 HSP25 和 HSP27 的磷酸化。

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Custom Peptide Synthesis

MK2-IN-5 Chemical Structure

MK2-IN-5 Chemical Structure

CAS No. : 474713-20-7

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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MK2-IN-5 的其他形式现货产品:

Customer Review

Other Forms of MK2-IN-5:

MK2-IN-5 相关抗体

Top Publications Citing Use of Products

查看 ERK 亚型特异性产品:

查看所有亚型
ERK ERK1 ERK2 ERK5 ERK8

查看 JNK 亚型特异性产品:

查看所有亚型
JNK1 JNK2 JNK3 JNK

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MK2-IN-5 is a Mk2 pseudosubstrate (Ki= 8 μM). MK2-IN-5 targets the protein interaction domain in the MAPK pathway. MK2-IN-5 inhibits HSP25 and HSP27 phosphorylation[1][2][3].

IC50 & Target

ERK1

 

ERK2

 

体外研究
(In Vitro)

MK2-IN-5 (5-10 μM, 2 h) 抑制 TGF-b1 诱导的人瘢痕疙瘩成纤维细胞中结缔组织生长因子和 I 型胶原的表达[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MK2-IN-5 相关抗体:
体内研究
(In Vivo)

MK2-IN-5 (2 mg/kg Intraperitoneal injection, single dose) 降低呼吸机相关性肺损伤模型中 HSP25 的磷酸化[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ventilator-associated lung injury model[2]
Dosage: 2 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Decreased HSP25 phosphorylation.
分子量

1396.68

Formula

C61H113N21O16
CAS 号
Sequence

Lys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala
Sequence Shortening

KKKALNRQLGVAA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MK2-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK2-IN-5474713-20-7Hsp25 kinase inhibitor Mk2 pseudosubstrateERKJNKp38 MAPKHSPMAPKAPK2 (MK2)Extracellular signal regulated kinasesc-Jun N-terminal kinaseHeat shock proteinsMitogen-activated protein kinase activated protein kinase 2MAP kinase activated protein kinase 2MAPK activated protein kinase 2MAPKAP kinase 2MAPKPeptideInhibitorinhibitorinhibit

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目录号：
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